Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-Xre
Location 1436584..1437454 Replicon plasmid pRgalR602c
Accession NZ_CP006880
Organism Rhizobium gallicum bv. gallicum R602

Toxin (Protein)


Gene name - Uniprot ID A0A0B4XFW2
Locus tag RGR602_RS29865 Protein ID WP_040115605.1
Coordinates 1436584..1437090 (-) Length 169 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0B4XFG1
Locus tag RGR602_RS29870 Protein ID WP_040115606.1
Coordinates 1437083..1437454 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RGR602_RS29855 1433012..1434451 + 1440 WP_082046730.1 FAD/NAD(P)-binding protein -
RGR602_RS29860 1434759..1436255 + 1497 WP_040116601.1 DegQ family serine endoprotease -
RGR602_RS29865 1436584..1437090 - 507 WP_040115605.1 RES domain-containing protein Toxin
RGR602_RS29870 1437083..1437454 - 372 WP_040115606.1 DUF2384 domain-containing protein Antitoxin
RGR602_RS29875 1437517..1438305 - 789 WP_040115607.1 crotonase/enoyl-CoA hydratase family protein -
RGR602_RS29880 1438305..1439174 - 870 WP_040115608.1 hydroxymethylglutaryl-CoA lyase -
RGR602_RS29885 1439174..1441153 - 1980 WP_040115609.1 acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katA / htpB 1..2466951 2466951


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(7-161)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(71-120)


Sequences

Toxin        


Download         Length: 169 a.a.        Molecular weight: 18899.74 Da        Isoelectric Point: 7.4013

>T45726 WP_040115605.1 NZ_CP006880:c1437090-1436584 [Rhizobium gallicum bv. gallicum R602]
MPEAVVHLWRAFVPRWAYAPLSGEGASRFGGRWNPVGAPTIYAACELSTAWAEYNQGFVQHPAMIVQLELKGARLADTTD
QELLRKFDVTADIHRCEWRMLMDESKVPATHHLRERLIASRYHGVIYPSFMSLGGTCVALWAWNMPGAPELRAIDPEGRL
PKSPASWL

Download         Length: 507 bp

>T45726 NZ_CP006880:c1437090-1436584 [Rhizobium gallicum bv. gallicum R602]
ATGCCTGAAGCCGTCGTGCATCTGTGGCGCGCCTTCGTTCCACGATGGGCCTATGCGCCGCTTTCTGGCGAGGGCGCCAG
CCGTTTTGGCGGTCGCTGGAATCCGGTGGGTGCCCCAACCATCTATGCGGCCTGCGAACTGTCCACGGCCTGGGCCGAAT
ATAACCAGGGCTTTGTCCAGCATCCGGCGATGATCGTGCAACTGGAACTCAAAGGGGCGCGCCTCGCCGACACGACAGAC
CAGGAGCTTCTTCGAAAGTTTGACGTTACTGCGGACATCCATCGTTGCGAATGGCGGATGCTGATGGATGAAAGCAAGGT
GCCGGCAACCCACCACTTGCGCGAACGTCTGATTGCGTCGCGATATCATGGCGTGATCTATCCATCCTTCATGTCGCTCG
GCGGCACATGCGTCGCGCTGTGGGCATGGAATATGCCGGGTGCACCGGAGCTTCGCGCAATTGATCCAGAGGGCCGACTG
CCCAAATCACCGGCCTCCTGGTTGTAG

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13117.02 Da        Isoelectric Point: 10.1453

>AT45726 WP_040115606.1 NZ_CP006880:c1437454-1437083 [Rhizobium gallicum bv. gallicum R602]
MAAIGLSNIAARFGDEHSSFLSARRVAEQLGVTLSELARLIGVARNTLAAKSSARKVDSALSNVVRILAMASEMTGDENR
AVIWFKHQPIPGWGGKTAFDLVGEGKSDRVLAYLEAVRSGVYA

Download         Length: 372 bp

>AT45726 NZ_CP006880:c1437454-1437083 [Rhizobium gallicum bv. gallicum R602]
ATGGCAGCCATAGGCCTCAGCAATATCGCTGCCCGCTTCGGCGATGAACATTCGTCGTTTCTATCGGCCCGTCGCGTCGC
CGAGCAACTCGGCGTAACGCTCTCCGAGCTGGCCCGGCTGATCGGGGTTGCGCGCAATACGCTGGCGGCGAAATCGAGCG
CCCGTAAAGTGGATAGTGCGCTGAGCAACGTCGTCCGCATCCTTGCCATGGCAAGCGAAATGACCGGCGACGAAAACCGC
GCGGTCATATGGTTCAAGCATCAGCCGATCCCCGGCTGGGGCGGCAAGACGGCTTTTGATCTTGTCGGTGAAGGCAAGTC
CGACCGGGTTCTCGCCTATCTGGAGGCCGTCCGCTCCGGCGTCTATGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B4XFW2

Antitoxin

Source ID Structure
AlphaFold DB A0A0B4XFG1

References