Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 394536..395212 Replicon plasmid pRgalR602c
Accession NZ_CP006880
Organism Rhizobium gallicum bv. gallicum R602

Toxin (Protein)


Gene name vapC Uniprot ID A0A0B4XCB5
Locus tag RGR602_RS25165 Protein ID WP_040114772.1
Coordinates 394787..395212 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0B4X8U8
Locus tag RGR602_RS25160 Protein ID WP_040116464.1
Coordinates 394536..394790 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RGR602_RS35055 391791..392441 + 651 WP_052451753.1 4'-phosphopantetheinyl transferase superfamily protein -
RGR602_RS25150 392473..393381 - 909 WP_040114770.1 DMT family transporter -
RGR602_RS25155 393472..394164 + 693 WP_040114771.1 metalloregulator ArsR/SmtB family transcription factor -
RGR602_RS25160 394536..394790 + 255 WP_040116464.1 plasmid stabilization protein Antitoxin
RGR602_RS25165 394787..395212 + 426 WP_040114772.1 type II toxin-antitoxin system VapC family toxin Toxin
RGR602_RS25170 396129..397193 + 1065 WP_040116465.1 ABC transporter ATP-binding protein -
RGR602_RS25175 397310..398335 + 1026 WP_040116466.1 Fe(3+) ABC transporter substrate-binding protein -
RGR602_RS25180 398378..400054 + 1677 WP_082046685.1 iron ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katA / htpB 1..2466951 2466951


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15268.69 Da        Isoelectric Point: 5.8650

>T45725 WP_040114772.1 NZ_CP006880:394787-395212 [Rhizobium gallicum bv. gallicum R602]
MILLDTNVISEPWKPVPEGTVIAWMDAQVIETLFLSAITIAELRFGIAVMPSGKRQSILRDRLEGEVLPHFAERILPFGL
ATSQFYSELMARARVSGKAIGRADGYIAATAAANGLAVATRDTSPFEAAGVKVINPWSLQQ

Download         Length: 426 bp

>T45725 NZ_CP006880:394787-395212 [Rhizobium gallicum bv. gallicum R602]
ATGATCTTGCTGGATACCAATGTGATATCGGAGCCGTGGAAGCCGGTTCCTGAAGGGACAGTGATCGCGTGGATGGACGC
CCAAGTCATCGAGACGCTGTTCCTTTCCGCGATAACAATTGCTGAACTTCGTTTCGGGATCGCTGTCATGCCCTCAGGCA
AACGGCAATCTATCCTTCGCGATCGCCTGGAGGGCGAAGTGCTTCCGCACTTTGCCGAGCGCATCCTGCCTTTCGGCCTT
GCCACCTCGCAGTTCTATTCGGAGCTGATGGCGCGCGCTCGAGTATCGGGGAAAGCGATAGGCAGGGCGGATGGTTATAT
TGCAGCGACAGCAGCAGCGAACGGCCTCGCCGTCGCAACTCGAGACACGAGCCCTTTCGAAGCCGCTGGGGTGAAAGTGA
TCAATCCTTGGTCACTACAACAATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9321.48 Da        Isoelectric Point: 6.4840

>AT45725 WP_040116464.1 NZ_CP006880:394536-394790 [Rhizobium gallicum bv. gallicum R602]
MPAVTIRNLSDETHRALRVRAAHHGRSTEAEIRDIIEAAVRPSERVKLGSLLAAIGRDAELSNHDIEALQQNRDKAPAEP
MTFE

Download         Length: 255 bp

>AT45725 NZ_CP006880:394536-394790 [Rhizobium gallicum bv. gallicum R602]
ATGCCGGCAGTCACAATTCGCAATCTTTCTGATGAAACGCATCGCGCCCTACGGGTGCGAGCAGCTCACCATGGCCGAAG
CACCGAGGCCGAAATCCGTGACATTATCGAGGCCGCCGTTCGTCCATCTGAACGCGTGAAACTCGGTTCCTTACTCGCGG
CCATAGGTCGTGACGCTGAGCTTTCCAACCACGACATTGAAGCCCTGCAGCAAAATCGCGATAAAGCGCCTGCCGAGCCG
ATGACTTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B4XCB5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B4X8U8

References