Detailed information of TA system TA045723

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 4052750..4054273
• Replicon: chromosome
• Accession: NZ_CP006877
• Organism: Rhizobium gallicum bv. gallicum R602

Toxin (Protein)

• Gene name: HipA1
• Uniprot ID: A0A0B4X986
• Locus tag: RGR602_RS19755
• Protein ID: WP_039846494.1
• Coordinates: 4053029..4054273 (+)
• Length: 415 a.a.

Antitoxin (Protein)

• Gene name: HipB1
• Uniprot ID: -
• Locus tag: RGR602_RS19750
• Protein ID: WP_039846493.1
• Coordinates: 4052750..4053016 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RGR602_RS19730	4048699..4049208	+	510	WP_039846490.1	DUF1993 domain-containing protein	-
RGR602_RS19735	4049213..4050799	-	1587	WP_082046584.1	alkaline phosphatase family protein	-
RGR602_RS19740	4050741..4051721	-	981	WP_039846491.1	UDP-glucose 4-epimerase GalE	-
RGR602_RS19750	4052750..4053016	+	267	WP_039846493.1	helix-turn-helix transcriptional regulator	Antitoxin
RGR602_RS19755	4053029..4054273	+	1245	WP_039846494.1	type II toxin-antitoxin system HipA family toxin	Toxin
RGR602_RS19760	4054844..4056280	+	1437	WP_039846495.1	hypothetical protein	-
RGR602_RS19770	4056806..4057117	+	312	WP_039846497.1	hypothetical protein	-
RGR602_RS19780	4057652..4057969	+	318	WP_039846498.1	50S ribosomal protein L21	-
RGR602_RS19785	4058004..4058273	+	270	WP_022717527.1	50S ribosomal protein L27	-
RGR602_RS19790	4058398..4059030	+	633	WP_039846499.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (3-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (9-66)

Sequences

Toxin

Protein

• Length: 415 a.a.
• Molecular weight: 45914.51 Da
• Isoelectric Point: 6.5050

>T45723 WP_039846494.1 NZ_CP006877:4053029-4054273 [Rhizobium gallicum bv. gallicum R602]
MTTIYYENWPVAYLTDDDGLSLAYDAEWEKRQSAFPLSLTMPLREGSHGPEKVMPWLANLLPEAHLSEIGQQLKVSPQDV
LGLLMRVGRDTAGAFSIGEPRRDGNNFRVVDDAEALERIINELPERPFLIGERGVSMSLAGVQDKLPVFINADGRIAIPL
DGTPSTHILKPDIRRLAGSVTNEAFCMTLARLCGLEAAEVTTGRAGERDYLLVRRYDRIADVQGIVRRIHQEDFCQLLGL
FPAEKYEQTGLGRRIGASLPQMFEALARLVSPAERLRLLDAVIFNVLICNSDSHAKNYSVLIGASGTARLAPLYDLMCAA
PYRQIDQSLPQRLGTRRNADELHGKDWRQFASDTGLSPAMVTRRVEELAGLVASRANEALTQVLSYPVSDRESGSSLAFL
VKKRCGRIERQIRG

Nucleotide

• Length: 1245 bp

>T45723 NZ_CP006877:4053029-4054273 [Rhizobium gallicum bv. gallicum R602]
TTGACCACCATCTACTACGAGAACTGGCCCGTCGCGTATCTCACCGATGATGATGGCCTCTCGCTTGCATATGATGCCGA
GTGGGAAAAACGGCAGTCCGCCTTTCCGCTATCGCTCACCATGCCGTTGCGCGAAGGCAGTCACGGACCTGAAAAGGTCA
TGCCATGGCTCGCCAATCTTCTGCCGGAGGCACACCTTTCCGAGATCGGTCAGCAACTGAAGGTCTCGCCGCAGGATGTC
CTCGGCCTGCTCATGCGCGTTGGGCGTGATACCGCAGGTGCGTTCTCGATCGGGGAGCCCCGTCGAGACGGAAACAATTT
CCGAGTCGTCGATGATGCGGAAGCGCTCGAGCGCATCATCAATGAACTGCCGGAACGGCCGTTCCTGATCGGCGAGAGAG
GCGTCTCGATGTCCCTTGCTGGCGTGCAGGACAAGCTGCCCGTCTTCATCAACGCGGACGGCAGGATCGCCATTCCGCTG
GACGGTACCCCATCGACCCATATCCTGAAACCCGACATCAGGCGTCTTGCGGGTAGTGTCACGAACGAAGCCTTCTGCAT
GACCCTCGCCAGGCTTTGCGGTCTCGAGGCCGCAGAGGTGACGACCGGTCGGGCAGGAGAGCGGGATTATCTCCTTGTCA
GACGCTATGACCGGATCGCAGATGTGCAAGGCATCGTTCGCCGGATACACCAAGAAGACTTCTGCCAGCTGCTGGGGCTC
TTCCCTGCGGAGAAATACGAGCAGACCGGTCTCGGACGGCGCATTGGCGCATCCCTCCCGCAGATGTTCGAGGCGCTCGC
GCGCCTTGTCTCGCCGGCAGAACGCCTTCGACTGCTCGACGCGGTGATCTTCAACGTCCTGATCTGCAATTCGGATTCGC
ATGCCAAGAACTATTCGGTGCTCATCGGCGCATCCGGTACCGCGAGACTTGCGCCCCTCTACGATCTGATGTGTGCGGCA
CCCTACCGTCAGATCGACCAGTCCCTGCCGCAGAGACTGGGGACCAGGCGGAATGCGGATGAGCTTCATGGAAAGGACTG
GCGTCAGTTCGCCTCCGATACAGGCCTCAGTCCCGCTATGGTCACGCGACGCGTGGAGGAGCTCGCCGGGCTAGTCGCGT
CCAGGGCGAATGAGGCGCTGACGCAGGTGCTTTCCTATCCGGTTTCGGACAGGGAATCCGGGTCCAGCCTTGCCTTCCTT
GTCAAGAAACGATGCGGACGGATCGAACGCCAGATTCGCGGCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9622.98 Da
• Isoelectric Point: 6.9501

>AT45723 WP_039846493.1 NZ_CP006877:4052750-4053016 [Rhizobium gallicum bv. gallicum R602]
MIRSASEFGALVRERRKTLGWTQIQLAERCGTGERFIVDLENGKPSCHLEKALIAARTVGLDLGDLKSMTPSAASSPDDD
LGYLPRFS

Nucleotide

• Length: 267 bp

>AT45723 NZ_CP006877:4052750-4053016 [Rhizobium gallicum bv. gallicum R602]
ATGATCCGTTCTGCCTCGGAATTCGGAGCGTTGGTCCGGGAACGCAGGAAAACGCTCGGATGGACCCAAATTCAGCTTGC
GGAACGATGCGGCACCGGTGAACGCTTCATCGTCGACCTGGAGAACGGCAAGCCGAGTTGCCATCTCGAAAAGGCTTTGA
TCGCGGCCCGGACGGTCGGTCTGGATCTCGGCGACCTGAAGTCAATGACGCCCTCTGCTGCTTCAAGCCCGGATGACGAT
CTCGGATATCTCCCACGCTTCTCCTGA

Structures

Toxin

• AlphaFold DB: A0A0B4X986