Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3178900..3179531 Replicon chromosome
Accession NZ_CP006877
Organism Rhizobium gallicum bv. gallicum R602

Toxin (Protein)


Gene name vapC Uniprot ID A0A0B4X7C1
Locus tag RGR602_RS15565 Protein ID WP_039845847.1
Coordinates 3178900..3179298 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0B4X2Y3
Locus tag RGR602_RS15570 Protein ID WP_039845848.1
Coordinates 3179298..3179531 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RGR602_RS15535 3173902..3176268 - 2367 WP_170250346.1 VirB4 family type IV secretion system protein -
RGR602_RS15540 3176261..3176599 - 339 WP_039845842.1 type IV secretion system protein VirB3 -
RGR602_RS15545 3176605..3176904 - 300 WP_039845843.1 TrbC/VirB2 family protein -
RGR602_RS15550 3176901..3177563 - 663 WP_039845844.1 transglycosylase SLT domain-containing protein -
RGR602_RS35705 3177567..3178088 - 522 WP_082046559.1 hypothetical protein -
RGR602_RS15555 3178182..3178535 + 354 WP_039845845.1 MarR family transcriptional regulator -
RGR602_RS15565 3178900..3179298 - 399 WP_039845847.1 tRNA(fMet)-specific endonuclease VapC Toxin
RGR602_RS15570 3179298..3179531 - 234 WP_039845848.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
RGR602_RS37230 3179737..3180048 + 312 WP_203226206.1 hypothetical protein -
RGR602_RS15580 3180232..3180756 + 525 WP_039845850.1 MbcA/ParS/Xre antitoxin family protein -
RGR602_RS15585 3180753..3181424 + 672 WP_039845851.1 RES family NAD+ phosphorylase -
RGR602_RS15590 3181795..3182004 + 210 WP_039846939.1 hypothetical protein -
RGR602_RS15595 3182219..3182683 - 465 WP_082046608.1 NUDIX domain-containing protein -
RGR602_RS15600 3182864..3184315 + 1452 WP_039845852.1 inorganic triphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14993.35 Da        Isoelectric Point: 6.7058

>T45721 WP_039845847.1 NZ_CP006877:c3179298-3178900 [Rhizobium gallicum bv. gallicum R602]
MLTYMLDTNICIYVMKNYPLELREKFNTLAEQLCISSITLGELYYGAEKSARRIENLIAVERFVVRLEVLPFADKAAAHY
GQVRTELERAGTPCGPHDMQIGGHARSEGLIVVTNNMREFARMPGVRAENWV

Download         Length: 399 bp

>T45721 NZ_CP006877:c3179298-3178900 [Rhizobium gallicum bv. gallicum R602]
ATGCTCACCTACATGCTCGATACGAATATCTGCATCTACGTGATGAAGAACTATCCACTGGAACTGCGTGAGAAATTCAA
CACGCTGGCCGAACAGCTCTGTATATCCAGCATCACGCTTGGAGAACTCTATTACGGGGCGGAAAAATCGGCTCGCCGCA
TCGAGAACCTGATTGCGGTCGAGCGATTCGTGGTGCGGCTGGAGGTGCTGCCTTTCGCAGACAAGGCGGCGGCGCACTAC
GGGCAGGTCCGGACCGAGCTTGAGCGAGCCGGAACGCCTTGCGGTCCCCATGACATGCAGATTGGCGGCCATGCCCGCAG
CGAAGGATTGATCGTCGTCACCAACAACATGCGGGAGTTCGCCCGAATGCCGGGCGTCCGGGCGGAAAACTGGGTGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8741.93 Da        Isoelectric Point: 7.0136

>AT45721 WP_039845848.1 NZ_CP006877:c3179531-3179298 [Rhizobium gallicum bv. gallicum R602]
MTSSTVFISNRSQAVRLPKAVAFPENVHLVDILKIGRSRVIVPQGKRWDDLFLSGPRVSEDFLSEREQPAAEERESF

Download         Length: 234 bp

>AT45721 NZ_CP006877:c3179531-3179298 [Rhizobium gallicum bv. gallicum R602]
ATGACCAGCTCCACGGTTTTCATCAGTAATCGCAGCCAGGCGGTCCGACTTCCCAAAGCCGTCGCCTTTCCTGAAAACGT
GCATCTGGTCGATATTCTCAAGATCGGCCGCAGCCGGGTAATCGTGCCCCAAGGCAAGCGGTGGGACGATCTGTTTCTGA
GCGGGCCGCGCGTCAGCGAGGATTTCCTGAGCGAACGTGAGCAACCGGCAGCGGAAGAACGCGAGTCGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B4X7C1

Antitoxin

Source ID Structure
AlphaFold DB A0A0B4X2Y3

References