Detailed information of TA system TA045719

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2551133..2552622
• Replicon: chromosome
• Accession: NZ_CP006877
• Organism: Rhizobium gallicum bv. gallicum R602

Toxin (Protein)

• Gene name: HipA1
• Uniprot ID: A0A0B4X1S1
• Locus tag: RGR602_RS12690
• Protein ID: WP_039845411.1
• Coordinates: 2551133..2552395 (-)
• Length: 421 a.a.

Antitoxin (Protein)

• Gene name: HipB1
• Uniprot ID: -
• Locus tag: RGR602_RS12695
• Protein ID: WP_039845412.1
• Coordinates: 2552392..2552622 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RGR602_RS12650	2546455..2547201	-	747	WP_039845405.1	SIMPL domain-containing protein	-
RGR602_RS37130	2547456..2547695	-	240	WP_052451550.1	hypothetical protein	-
RGR602_RS37135	2548175..2548342	+	168	Protein_2486	IS5/IS1182 family transposase	-
RGR602_RS12670	2548417..2549028	-	612	WP_039845407.1	hypothetical protein	-
RGR602_RS12675	2549475..2549771	+	297	WP_039845408.1	hypothetical protein	-
RGR602_RS37140	2550150..2550401	+	252	WP_170251342.1	hypothetical protein	-
RGR602_RS12680	2550491..2550775	+	285	WP_039845409.1	hypothetical protein	-
RGR602_RS12690	2551133..2552395	-	1263	WP_039845411.1	type II toxin-antitoxin system HipA family toxin	Toxin
RGR602_RS12695	2552392..2552622	-	231	WP_039845412.1	helix-turn-helix transcriptional regulator	Antitoxin
RGR602_RS12700	2553408..2555576	-	2169	WP_039845413.1	glycosyltransferase	-
RGR602_RS12705	2555561..2556763	-	1203	Protein_2494	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (6-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-69)

Sequences

Toxin

Protein

• Length: 421 a.a.
• Molecular weight: 45677.38 Da
• Isoelectric Point: 4.8389

>T45719 WP_039845411.1 NZ_CP006877:c2552395-2551133 [Rhizobium gallicum bv. gallicum R602]
MMTKVLNVWWDGSIVGQFTQDRHGDIGFAYAQAWLDDETALPLSASLPKRLERFSRRECRPFFGGLLPEESQRLVAAQAL
GVSPANDFALLDRLGGDVAGALQLLPEDQEPVRTEPLADQQITPLDEAGIVRILDALPTRPLLAGQEGLRLSLAGAQSKV
PLVLIDGQLALPVPGQATTHILKPPIARFPGTTDTEAFVMKLAAAIGLEVAPVEPRSANGRPFLLVERYDRYRDANDVVR
RIHQEDFCQALGVPPETKYASEGGPTFKDCFELLRRVSERPATDLAKLMDAAIFNLIVGNADAHGKNFSILYDDLGPRMA
PFYDLLSTVAYPDLSPKMAMRIGNRATLAEMDADGWKAFAKETGIGLLLVRRRVKELADATGEAIAQVSETVSPLAIDPE
TTNHVAALIADRAKLVSLSI

Nucleotide

• Length: 1263 bp

>T45719 NZ_CP006877:c2552395-2551133 [Rhizobium gallicum bv. gallicum R602]
ATGATGACGAAGGTTCTTAACGTCTGGTGGGACGGTAGCATTGTCGGACAGTTCACGCAGGACAGGCACGGCGACATAGG
GTTCGCCTATGCTCAGGCTTGGCTTGACGACGAAACCGCTCTTCCGCTTTCGGCTTCTCTTCCGAAGCGACTGGAGCGCT
TCTCCCGTCGAGAATGTAGGCCGTTTTTCGGTGGCCTGCTGCCCGAGGAAAGCCAACGCCTGGTTGCCGCGCAGGCATTA
GGCGTTTCACCTGCGAACGACTTTGCGCTTCTCGATCGCTTAGGGGGCGACGTCGCCGGCGCCCTCCAGCTTTTGCCGGA
AGACCAGGAACCCGTTAGGACAGAGCCGCTCGCAGACCAGCAGATTACACCCCTCGATGAGGCCGGAATCGTTCGGATAC
TCGACGCACTTCCGACACGGCCGCTATTGGCCGGCCAAGAAGGCTTGAGGCTATCGCTGGCCGGCGCGCAATCTAAGGTG
CCGCTTGTTTTAATCGACGGCCAGCTCGCGCTTCCAGTTCCCGGCCAGGCAACAACGCATATTCTGAAACCGCCAATCGC
GCGCTTCCCAGGGACGACCGATACCGAAGCTTTCGTGATGAAACTCGCTGCAGCGATCGGCCTCGAGGTCGCACCGGTCG
AACCGAGGTCAGCGAATGGGCGCCCCTTTCTCCTGGTCGAGCGATACGATCGCTATCGCGACGCCAATGATGTTGTTCGC
CGCATCCACCAAGAAGACTTTTGCCAAGCACTTGGTGTGCCGCCTGAAACGAAGTATGCGAGCGAGGGCGGGCCGACCTT
CAAGGATTGTTTCGAGTTGTTGCGGCGGGTGTCTGAACGGCCGGCTACGGACCTCGCTAAACTAATGGACGCTGCTATTT
TCAATCTCATTGTCGGAAATGCGGACGCCCACGGCAAGAATTTCTCGATCCTTTATGACGATCTGGGACCGAGAATGGCT
CCGTTTTACGACCTGCTTTCCACCGTGGCCTATCCAGACCTTTCGCCGAAAATGGCTATGCGGATCGGAAACCGCGCAAC
GCTTGCCGAAATGGACGCCGACGGTTGGAAGGCTTTTGCGAAGGAGACCGGGATTGGCTTACTCTTGGTACGCCGCCGAG
TTAAGGAGCTAGCTGATGCCACAGGTGAAGCGATAGCCCAAGTGTCAGAAACGGTATCTCCACTTGCCATCGATCCCGAG
ACGACAAATCACGTGGCGGCCTTGATCGCAGACCGCGCTAAACTCGTTTCTCTCTCGATCTAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8021.38 Da
• Isoelectric Point: 10.7495

>AT45719 WP_039845412.1 NZ_CP006877:c2552622-2552392 [Rhizobium gallicum bv. gallicum R602]
MAKQVRSPADIGALVRSARKEQNLRQDELAGVAGVGLRFIVDLEAGKPTAQIGKVLQVLQTLGCSVVILAPGEGRR

Nucleotide

• Length: 231 bp

>AT45719 NZ_CP006877:c2552622-2552392 [Rhizobium gallicum bv. gallicum R602]
ATGGCAAAACAAGTCAGAAGTCCAGCCGACATCGGCGCCCTGGTCCGGAGTGCACGCAAGGAGCAAAACTTGCGGCAGGA
TGAGCTTGCCGGCGTTGCTGGCGTTGGCCTGCGGTTCATTGTCGATCTCGAAGCAGGTAAGCCCACGGCTCAGATTGGAA
AAGTGCTCCAGGTTCTCCAAACGCTCGGTTGCTCTGTTGTTATTTTAGCCCCTGGCGAGGGTAGGCGATGA

Structures

Toxin

• AlphaFold DB: A0A0B4X1S1