Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5099872..5100539 Replicon chromosome
Accession NZ_CP006857
Organism Xanthomonas citri subsp. citri A306

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag J151_RS22265 Protein ID WP_005916679.1
Coordinates 5100123..5100539 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag J151_RS22260 Protein ID WP_005916676.1
Coordinates 5099872..5100126 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J151_RS22235 5095994..5096213 + 220 Protein_4255 RNA 2'-phosphotransferase -
J151_RS22240 5096370..5097635 + 1266 WP_015463799.1 cardiolipin synthase B -
J151_RS22245 5097661..5098188 - 528 WP_005916668.1 hypothetical protein -
J151_RS22250 5098427..5098633 + 207 WP_003489327.1 hypothetical protein -
J151_RS22255 5098620..5099726 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
J151_RS22260 5099872..5100126 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
J151_RS22265 5100123..5100539 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
J151_RS25235 5100661..5100864 - 204 WP_125460668.1 hypothetical protein -
J151_RS25240 5100992..5101204 - 213 WP_015472901.1 hypothetical protein -
J151_RS22270 5101461..5103080 + 1620 WP_015463800.1 hypothetical protein -
J151_RS22275 5103184..5103582 - 399 WP_004429277.1 DUF2384 domain-containing protein -
J151_RS22280 5103898..5104329 + 432 WP_005922907.1 hypothetical protein -
J151_RS24750 5104358..5104684 - 327 Protein_4267 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T45717 WP_005916679.1 NZ_CP006857:5100123-5100539 [Xanthomonas citri subsp. citri A306]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T45717 NZ_CP006857:5100123-5100539 [Xanthomonas citri subsp. citri A306]
GTGATCCTGCTCGATACCAATGTCATCTCCGAACTTTGGCGGCCTCAGCCTAATCCGCAGGTCGTCGCCTGGATCGATGC
ACAAGCTGTCGAGACACTGTTCCTGTCGGTCGTGACGGTGGCTGAACTCCGTTTCGGTATTGCCGTGATGCCCAAGGGCC
GAAAGCGATCCACCTTGCATGCTCGGTTGGAGGGCGAGGTATTGCCACTGTTCGACGGGCGCCTGCTCGCATTCGATCTG
GATGCATCACACGCATTTGCGGCGCTTGCATCGAAAGCCAGAACCGCAGGACTCACACTCGGGCGCGCCGATGCCTACAT
CGCTGCAACAGCAGCCGCGCAAGGATTGACCGTTGCCACTCGCGACACGGCACCATTCGAGGCGATGGCGTTAGACGTCA
TTAACCCTTGGAGTTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT45717 WP_005916676.1 NZ_CP006857:5099872-5100126 [Xanthomonas citri subsp. citri A306]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT45717 NZ_CP006857:5099872-5100126 [Xanthomonas citri subsp. citri A306]
ATGCCTTCTTTCACCGTCCGCAATATCCCAGACGACGTGCATCGCGCGATCCGCGCGCGGGCTGCACTTCATGGCCGCAG
CACCGAAGCGGAGATCCGCGCAATCCTTGAATTGGCGGCCAAACCCGCAGACCGGGTCAAACTCGGCTCACTGCTGGTGA
GCATCGGCCGCGACGCCGGCCTGACCGCAAAAGAGGCCAATGCCTTCGACAAGCTGCGCGGCAAGGCGGCGATCAAGCCG
ATCGGTCTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References