Detailed information of TA system TA045714

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-MazE
• Location: 2561146..2561779
• Replicon: chromosome
• Accession: NZ_CP006857
• Organism: Xanthomonas citri subsp. citri A306

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: J151_RS11625
• Protein ID: WP_015463212.1
• Coordinates: 2561146..2561559 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M4TWF0
• Locus tag: J151_RS11630
• Protein ID: WP_015463213.1
• Coordinates: 2561546..2561779 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J151_RS11615	2556838..2559018	+	2181	WP_011051394.1	TonB-dependent siderophore receptor	-
J151_RS11620	2559227..2560741	+	1515	WP_015463210.1	conjugal transfer protein TraG N-terminal domain-containing protein	-
J151_RS23725	2560757..2561119	-	363	WP_015463211.1	DUF3742 family protein	-
J151_RS11625	2561146..2561559	-	414	WP_015463212.1	PIN domain-containing protein	Toxin
J151_RS11630	2561546..2561779	-	234	WP_015463213.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
J151_RS11635	2562037..2563068	+	1032	WP_040107627.1	DUF4917 family protein	-
J151_RS11640	2563201..2563599	-	399	WP_099521978.1	hypothetical protein	-
J151_RS11645	2564051..2564626	+	576	WP_011051400.1	sigma-70 family RNA polymerase sigma factor	-
J151_RS11650	2564607..2565656	+	1050	WP_011051401.1	FecR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-119)

Antitoxin

• SpoVT-AbrB domain (5-45)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15221.65 Da
• Isoelectric Point: 6.3225

>T45714 WP_015463212.1 NZ_CP006857:c2561559-2561146 [Xanthomonas citri subsp. citri A306]
MAAGKGKVFLDSNVVLYLLSEDAVKADGAEALLQRRPVISVQVLNEVTHVCVRKLKMGWDEVGQFLALVRSFCKIVPLTV
DVHDRARQLAERHQLSFYDACIVAAAAIEGCQTLYSEDMHHGLIIEESLSIRNPFNV

Nucleotide

• Length: 414 bp

>T45714 NZ_CP006857:c2561559-2561146 [Xanthomonas citri subsp. citri A306]
ATGGCCGCGGGTAAGGGCAAAGTGTTTCTCGACAGCAACGTGGTGCTCTACCTGCTGTCGGAGGATGCGGTGAAGGCGGA
CGGCGCGGAGGCATTGCTGCAGCGCAGGCCCGTCATCAGTGTGCAGGTGCTCAATGAAGTGACCCACGTCTGCGTTCGCA
AGCTCAAGATGGGCTGGGACGAAGTCGGGCAGTTCCTTGCGTTGGTGCGATCGTTCTGCAAGATAGTGCCTCTGACGGTC
GATGTTCACGACCGTGCGCGCCAGCTGGCGGAGCGGCACCAATTGTCGTTCTACGACGCGTGCATCGTGGCGGCGGCCGC
CATCGAAGGGTGCCAGACCCTCTACTCCGAAGACATGCACCACGGCCTCATCATCGAAGAGAGCCTGTCGATTCGGAACC
CGTTCAACGTCTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8663.97 Da
• Isoelectric Point: 8.7848

>AT45714 WP_015463213.1 NZ_CP006857:c2561779-2561546 [Xanthomonas citri subsp. citri A306]
MQVAKWGNSLAVRLPSSLVEALELREGDDIEIVVDDPRLFAVRKKPGPEAMLERLRAFRGKLPADFKFNRDEANGRG

Nucleotide

• Length: 234 bp

>AT45714 NZ_CP006857:c2561779-2561546 [Xanthomonas citri subsp. citri A306]
ATGCAAGTCGCGAAGTGGGGTAACAGCCTGGCGGTGCGCCTGCCGTCCAGTCTGGTGGAAGCGCTGGAACTGCGCGAGGG
CGACGACATCGAGATCGTCGTCGATGATCCGCGATTGTTCGCGGTGCGCAAGAAGCCGGGTCCGGAGGCCATGTTGGAGC
GGCTGCGTGCCTTCCGGGGCAAGTTGCCCGCAGATTTCAAGTTCAACCGGGACGAGGCCAATGGCCGCGGGTAA

Structures

Antitoxin

• AlphaFold DB: M4TWF0