Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 31393..31934 Replicon plasmid pXAC64
Accession NZ_CP006856
Organism Xanthomonas citri subsp. citri A306

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag J151_RS00320 Protein ID WP_015462614.1
Coordinates 31393..31719 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID H8FMA7
Locus tag J151_RS00325 Protein ID WP_003491150.1
Coordinates 31716..31934 (-) Length 73 a.a.

Genomic Context

J151_RS00310J151_RS00315J151_RS00320J151_RS00325J151_RS00330J151_RS00335J151_RS00340J151_RS00345J151_RS00350
Location: 26776..28350 (1575 bp)
Type: Others
Protein ID: WP_011052977.1
Location: 28364..31339 (2976 bp)
Type: Others
Protein ID: WP_011052978.1
Location: 31393..31719 (327 bp)
Type: Toxin
Protein ID: WP_015462614.1
Location: 31716..31934 (219 bp)
Type: Antitoxin
Protein ID: WP_003491150.1
Location: 32071..32457 (387 bp)
Type: Others
Protein ID: WP_003491149.1
Location: 32534..32953 (420 bp)
Type: Others
Protein ID: WP_011052981.1
Location: 33079..33957 (879 bp)
Type: Others
Protein ID: WP_011052982.1
Location: 33968..34990 (1023 bp)
Type: Others
Protein ID: WP_011052983.1
Location: 35001..36221 (1221 bp)
Type: Others
Protein ID: WP_011052984.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
J151_RS0031026776..28350+1575WP_011052977.1type IV secretion system DNA-binding domain-containing protein-
J151_RS0031528364..31339+2976WP_011052978.1conjugative relaxase-
J151_RS0032031393..31719-327WP_015462614.1type II toxin-antitoxin system PemK/MazF family toxinToxin
J151_RS0032531716..31934-219WP_003491150.1antitoxin MazE family proteinAntitoxin
J151_RS0033032071..32457-387WP_003491149.1hypothetical protein-
J151_RS0033532534..32953-420WP_011052981.1hypothetical protein-
J151_RS0034033079..33957-879WP_011052982.1transglycosylase SLT domain-containing protein-
J151_RS0034533968..34990-1023WP_011052983.1P-type DNA transfer ATPase VirB11-
J151_RS0035035001..36221-1221WP_011052984.1TrbI/VirB10 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..6492064920


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Antitoxin MazE-like

(5-70)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11676.70 Da        Isoelectric Point: 9.2550

>T45711 WP_015462614.1 NZ_CP006856:c31719-31393 [Xanthomonas citri subsp. citri A306]
MMRGDFVTIAMQGDFGKPRPALVIQADQFDAHTTVTVLPVTSTLVAAPLLRITVHPSTDNGLQKPSQVMVDKAMTVKRDK
VGRAFGRVDADALVEIERCLAVFLGIAK

Download         Length: 327 bp

>T45711 NZ_CP006856:c31719-31393 [Xanthomonas citri subsp. citri A306]
ATGATGCGGGGTGACTTTGTGACCATCGCCATGCAAGGCGACTTCGGAAAACCAAGGCCCGCTCTGGTGATCCAGGCCGA
CCAGTTTGACGCACACACCACCGTGACGGTGCTGCCGGTGACAAGCACGCTCGTTGCTGCGCCGCTGCTGCGTATTACCG
TTCATCCAAGTACCGACAATGGTTTGCAGAAGCCGTCTCAGGTGATGGTGGACAAGGCCATGACCGTGAAGCGTGACAAG
GTAGGTCGAGCCTTTGGGCGCGTAGACGCTGATGCGTTGGTGGAAATTGAGCGCTGCCTGGCCGTGTTCTTGGGCATCGC
TAAGTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8418.54 Da        Isoelectric Point: 5.6599

>AT45711 WP_003491150.1 NZ_CP006856:c31934-31716 [Xanthomonas citri subsp. citri A306]
MAHVNSRVQKHRDALRMAGLRPVQIWVPDTRRPDFAEECRRQCRLAAQADMADTDMQRFMDEALADMDGWTE

Download         Length: 219 bp

>AT45711 NZ_CP006856:c31934-31716 [Xanthomonas citri subsp. citri A306]
ATGGCACACGTCAATTCACGAGTTCAAAAGCACCGCGACGCCCTGCGCATGGCAGGGCTGCGTCCGGTGCAAATTTGGGT
GCCGGACACACGGCGGCCTGACTTCGCCGAGGAATGCCGCCGTCAGTGTCGTCTTGCTGCACAAGCGGACATGGCGGATA
CCGACATGCAGCGCTTCATGGATGAGGCGCTAGCAGACATGGATGGCTGGACGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBH8FMA7

References