Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 6994649..6995168 Replicon chromosome
Accession NZ_CP006850
Organism Nocardia nova SH22a

Toxin (Protein)


Gene name relE Uniprot ID W5TQ28
Locus tag NONO_RS31980 Protein ID WP_025352582.1
Coordinates 6994899..6995168 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W5TQN0
Locus tag NONO_RS31975 Protein ID WP_025352581.1
Coordinates 6994649..6994906 (+) Length 86 a.a.

Genomic Context

NONO_RS31960NONO_RS31965NONO_RS31975NONO_RS31980NONO_RS31950NONO_RS31955NONO_RS31970NONO_RS31985NONO_RS31990NONO_RS31995
Location: 6992042..6992632 (591 bp)
Type: Others
Protein ID: WP_148307037.1
Location: 6992716..6993939 (1224 bp)
Type: Others
Protein ID: WP_025352579.1
Location: 6994649..6994906 (258 bp)
Type: Antitoxin
Protein ID: WP_025352581.1
Location: 6994899..6995168 (270 bp)
Type: Toxin
Protein ID: WP_025352582.1
Location: 6990351..6991190 (840 bp)
Type: Others
Protein ID: WP_025352576.1
Location: 6991471..6991719 (249 bp)
Type: Others
Protein ID: WP_081769825.1
Location: 6994040..6994594 (555 bp)
Type: Others
Protein ID: WP_202807949.1
Location: 6995195..6996400 (1206 bp)
Type: Others
Protein ID: WP_025352583.1
Location: 6996411..6997289 (879 bp)
Type: Others
Protein ID: WP_038555432.1
Location: 6997438..6998121 (684 bp)
Type: Others
Protein ID: WP_158436400.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NONO_RS319506990351..6991190-840WP_025352576.1mycofactocin-coupled SDR family oxidoreductase-
NONO_RS319556991471..6991719-249WP_081769825.1hypothetical protein-
NONO_RS319606992042..6992632+591WP_148307037.1hypothetical protein-
NONO_RS319656992716..6993939+1224WP_025352579.1DUF2236 domain-containing protein-
NONO_RS319706994040..6994594-555WP_202807949.1GNAT family N-acetyltransferase-
NONO_RS319756994649..6994906+258WP_025352581.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
NONO_RS319806994899..6995168+270WP_025352582.1Txe/YoeB family addiction module toxinToxin
NONO_RS319856995195..6996400-1206WP_025352583.1FAD-dependent monooxygenase-
NONO_RS319906996411..6997289-879WP_038555432.1alpha/beta hydrolase-
NONO_RS319956997438..6998121-684WP_158436400.1GAP family protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-66)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10120.57 Da        Isoelectric Point: 9.4818

>T45709 WP_025352582.1 NZ_CP006850:6994899-6995168 [Nocardia nova SH22a]
MTERKLVFTAYGWETYTSWLTRDRTILKAANKLINAVLADPFTGIGKPEPLKHQLAGNWSRRISREHRLIYAVTDTEIIV
VGVGGNYDD

Download         Length: 270 bp

>T45709 NZ_CP006850:6994899-6995168 [Nocardia nova SH22a]
ATGACTGAGCGCAAGCTCGTCTTCACCGCCTACGGGTGGGAGACCTACACATCGTGGCTCACACGTGATCGCACGATTCT
GAAGGCAGCCAACAAGCTGATCAACGCGGTGCTCGCCGATCCGTTCACCGGCATCGGTAAACCCGAGCCACTCAAACATC
AACTTGCCGGAAACTGGTCCCGCCGAATATCCCGAGAGCACCGCCTGATCTACGCCGTGACCGACACCGAGATCATCGTC
GTCGGCGTCGGCGGCAACTACGACGACTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9372.36 Da        Isoelectric Point: 4.0932

>AT45709 WP_025352581.1 NZ_CP006850:6994649-6994906 [Nocardia nova SH22a]
MTALPISTVRQQLFSLVQQVNDDHDTVTVVTKSGENAVLVSEADWNSIQETLYVLATHGGVRLLESARAAERGEFEAREL
LDTDD

Download         Length: 258 bp

>AT45709 NZ_CP006850:6994649-6994906 [Nocardia nova SH22a]
ATGACCGCATTACCGATCTCGACCGTTCGCCAGCAGCTGTTCTCGCTGGTGCAGCAGGTCAACGATGACCACGACACGGT
CACCGTCGTGACCAAGAGCGGCGAGAACGCTGTGCTCGTATCCGAGGCGGACTGGAACTCCATTCAGGAAACGCTGTACG
TCCTGGCCACTCACGGTGGAGTTCGTCTGCTCGAATCCGCACGTGCGGCGGAACGAGGCGAGTTCGAGGCGCGCGAACTG
CTGGATACCGATGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBW5TQ28

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBW5TQN0

References