45709

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 6994649..6995168 Replicon chromosome
Accession NZ_CP006850
Organism Nocardia nova SH22a

Toxin (Protein)


Gene name relE Uniprot ID W5TQ28
Locus tag NONO_RS31980 Protein ID WP_025352582.1
Coordinates 6994899..6995168 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W5TQN0
Locus tag NONO_RS31975 Protein ID WP_025352581.1
Coordinates 6994649..6994906 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NONO_RS31950 6990351..6991190 - 840 WP_025352576.1 mycofactocin-coupled SDR family oxidoreductase -
NONO_RS31955 6991471..6991719 - 249 WP_081769825.1 hypothetical protein -
NONO_RS31960 6992042..6992632 + 591 WP_148307037.1 hypothetical protein -
NONO_RS31965 6992716..6993939 + 1224 WP_025352579.1 DUF2236 domain-containing protein -
NONO_RS31970 6994040..6994594 - 555 WP_202807949.1 GNAT family N-acetyltransferase -
NONO_RS31975 6994649..6994906 + 258 WP_025352581.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NONO_RS31980 6994899..6995168 + 270 WP_025352582.1 Txe/YoeB family addiction module toxin Toxin
NONO_RS31985 6995195..6996400 - 1206 WP_025352583.1 FAD-dependent monooxygenase -
NONO_RS31990 6996411..6997289 - 879 WP_038555432.1 alpha/beta hydrolase -
NONO_RS31995 6997438..6998121 - 684 WP_158436400.1 GAP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-66)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10120.57 Da        Isoelectric Point: 9.4818

>T45709 WP_025352582.1 NZ_CP006850:6994899-6995168 [Nocardia nova SH22a]
MTERKLVFTAYGWETYTSWLTRDRTILKAANKLINAVLADPFTGIGKPEPLKHQLAGNWSRRISREHRLIYAVTDTEIIV
VGVGGNYDD

Download         Length: 270 bp

>T45709 NZ_CP006850:6994899-6995168 [Nocardia nova SH22a]
ATGACTGAGCGCAAGCTCGTCTTCACCGCCTACGGGTGGGAGACCTACACATCGTGGCTCACACGTGATCGCACGATTCT
GAAGGCAGCCAACAAGCTGATCAACGCGGTGCTCGCCGATCCGTTCACCGGCATCGGTAAACCCGAGCCACTCAAACATC
AACTTGCCGGAAACTGGTCCCGCCGAATATCCCGAGAGCACCGCCTGATCTACGCCGTGACCGACACCGAGATCATCGTC
GTCGGCGTCGGCGGCAACTACGACGACTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9372.36 Da        Isoelectric Point: 4.0932

>AT45709 WP_025352581.1 NZ_CP006850:6994649-6994906 [Nocardia nova SH22a]
MTALPISTVRQQLFSLVQQVNDDHDTVTVVTKSGENAVLVSEADWNSIQETLYVLATHGGVRLLESARAAERGEFEAREL
LDTDD

Download         Length: 258 bp

>AT45709 NZ_CP006850:6994649-6994906 [Nocardia nova SH22a]
ATGACCGCATTACCGATCTCGACCGTTCGCCAGCAGCTGTTCTCGCTGGTGCAGCAGGTCAACGATGACCACGACACGGT
CACCGTCGTGACCAAGAGCGGCGAGAACGCTGTGCTCGTATCCGAGGCGGACTGGAACTCCATTCAGGAAACGCTGTACG
TCCTGGCCACTCACGGTGGAGTTCGTCTGCTCGAATCCGCACGTGCGGCGGAACGAGGCGAGTTCGAGGCGCGCGAACTG
CTGGATACCGATGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W5TQ28

Antitoxin

Source ID Structure
AlphaFold DB W5TQN0

References