Detailed information of TA system TA045707

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1260963..1261525
• Replicon: chromosome
• Accession: NZ_CP006842
• Organism: Corynebacterium glyciniphilum AJ 3170

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: X5DQS8
• Locus tag: CGLY_RS05935
• Protein ID: WP_038547320.1
• Coordinates: 1260963..1261331 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: X5E860
• Locus tag: CGLY_RS05940
• Protein ID: WP_038547323.1
• Coordinates: 1261346..1261525 (-)
• Length: 60 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGLY_RS05900	1256037..1256648	-	612	WP_038547310.1	NAD(P)H-dependent oxidoreductase	-
CGLY_RS05905	1256817..1257446	+	630	WP_038551589.1	TetR/AcrR family transcriptional regulator	-
CGLY_RS05910	1257539..1257925	-	387	WP_038547313.1	MerR family transcriptional regulator	-
CGLY_RS05915	1257988..1259178	+	1191	WP_081803800.1	MFS transporter	-
CGLY_RS05920	1259175..1260077	+	903	WP_038547316.1	NADP-dependent oxidoreductase	-
CGLY_RS05925	1260048..1260488	-	441	WP_038547317.1	carboxymuconolactone decarboxylase family protein	-
CGLY_RS05930	1260485..1260916	-	432	WP_081803801.1	MerR family transcriptional regulator	-
CGLY_RS05935	1260963..1261331	-	369	WP_038547320.1	type II toxin-antitoxin system VapC family toxin	Toxin
CGLY_RS05940	1261346..1261525	-	180	WP_038547323.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
CGLY_RS05945	1261578..1262735	-	1158	WP_038547326.1	MFS transporter	-
CGLY_RS05950	1262810..1263415	-	606	WP_038547329.1	TetR/AcrR family transcriptional regulator	-
CGLY_RS05955	1263598..1263795	+	198	WP_038547332.1	CsbD family protein	-
CGLY_RS05960	1263816..1264076	+	261	WP_052539751.1	DUF1049 domain-containing protein	-
CGLY_RS05965	1264126..1264425	+	300	WP_052539753.1	GlsB/YeaQ/YmgE family stress response membrane protein	-
CGLY_RS05970	1264370..1265389	-	1020	WP_169736923.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13564.51 Da
• Isoelectric Point: 5.5386

>T45707 WP_038547320.1 NZ_CP006842:c1261331-1260963 [Corynebacterium glyciniphilum AJ 3170]
VILVDTSVWIDHLHHAEKEIVELLGDDLVLSHAGVIEELALGSMREREAFTGFLSSLERCPSLTHEELMTFVEGARLWGR
GLSVIDVHLLGSARLAGSAIWTRDKRFREAAKQVGVSVYEGR

Nucleotide

• Length: 369 bp

>T45707 NZ_CP006842:c1261331-1260963 [Corynebacterium glyciniphilum AJ 3170]
GTGATTCTCGTCGATACCTCGGTCTGGATAGACCATCTTCATCACGCCGAGAAGGAAATCGTCGAACTGCTCGGCGATGA
CCTGGTCCTCAGCCACGCAGGCGTCATAGAGGAACTCGCCCTGGGCTCCATGAGGGAGCGTGAGGCCTTCACCGGGTTCC
TGAGTTCGCTGGAGCGATGCCCGAGTCTCACACACGAAGAATTGATGACATTCGTGGAGGGTGCGAGGCTCTGGGGACGG
GGGCTGAGCGTTATCGATGTCCACCTACTGGGTTCCGCCCGTCTCGCCGGCTCGGCAATCTGGACCAGGGACAAGCGCTT
CCGAGAGGCCGCGAAACAGGTGGGAGTCAGCGTCTACGAGGGACGGTGA

Antitoxin

Protein

• Length: 60 a.a.
• Molecular weight: 6409.36 Da
• Isoelectric Point: 4.9814

>AT45707 WP_038547323.1 NZ_CP006842:c1261525-1261346 [Corynebacterium glyciniphilum AJ 3170]
MRITVTIDDRLMERARELTGIDECSVLLRAGLESLIRVESARRLAALGGSDPDATAAPR

Nucleotide

• Length: 180 bp

>AT45707 NZ_CP006842:c1261525-1261346 [Corynebacterium glyciniphilum AJ 3170]
ATGAGGATAACCGTGACGATCGACGACAGGCTCATGGAGAGGGCACGCGAGCTGACCGGCATCGACGAATGCTCCGTCCT
CCTCCGCGCAGGTCTGGAATCCCTCATCCGCGTCGAGAGTGCACGTCGCCTGGCGGCGCTCGGAGGTTCAGACCCCGACG
CGACCGCCGCGCCCCGGTAA

Structures

Toxin

• AlphaFold DB: X5DQS8

Antitoxin

• AlphaFold DB: X5E860