Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4326400..4327198 Replicon chromosome
Accession NZ_CP006834
Organism Escherichia coli APEC O2-211

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag APECO2_RS22595 Protein ID WP_000854735.1
Coordinates 4326821..4327198 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A067H947
Locus tag APECO2_RS22590 Protein ID WP_001285415.1
Coordinates 4326400..4326774 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APECO2_RS22555 4322331..4323011 + 681 WP_001282919.1 WYL domain-containing protein -
APECO2_RS22560 4323159..4323836 + 678 WP_001097302.1 hypothetical protein -
APECO2_RS22565 4323842..4324075 + 234 WP_001278287.1 DUF905 family protein -
APECO2_RS22570 4324165..4324983 + 819 WP_001175148.1 DUF945 domain-containing protein -
APECO2_RS22575 4325065..4325544 + 480 WP_000844100.1 antirestriction protein -
APECO2_RS22580 4325560..4326036 + 477 WP_001366855.1 RadC family protein -
APECO2_RS22585 4326099..4326320 + 222 WP_000692309.1 DUF987 domain-containing protein -
APECO2_RS22590 4326400..4326774 + 375 WP_001285415.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
APECO2_RS22595 4326821..4327198 + 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
APECO2_RS22600 4327195..4327683 + 489 WP_000761677.1 hypothetical protein -
APECO2_RS22605 4327695..4327892 + 198 WP_000839291.1 DUF957 domain-containing protein -
APECO2_RS22610 4327977..4328843 + 867 WP_001280433.1 DUF4942 domain-containing protein -
APECO2_RS22615 4328915..4329178 + 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
APECO2_RS22620 4329175..4329501 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
APECO2_RS22625 4329965..4331227 + 1263 WP_001218801.1 integrase arm-type DNA-binding domain-containing protein -
APECO2_RS22635 4331589..4331753 - 165 WP_000065819.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T45702 WP_000854735.1 NZ_CP006834:4326821-4327198 [Escherichia coli APEC O2-211]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T45702 NZ_CP006834:4326821-4327198 [Escherichia coli APEC O2-211]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13663.32 Da        Isoelectric Point: 5.8640

>AT45702 WP_001285415.1 NZ_CP006834:4326400-4326774 [Escherichia coli APEC O2-211]
VSDTHPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT45702 NZ_CP006834:4326400-4326774 [Escherichia coli APEC O2-211]
GTGTCAGACACACACCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGGCAGT
TTAGCGACGCGGATGCGTATCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A067H947

References