Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1202569..1203367 Replicon chromosome
Accession NZ_CP006834
Organism Escherichia coli APEC O2-211

Toxin (Protein)


Gene name yeeV Uniprot ID Q8VRA6
Locus tag APECO2_RS06265 Protein ID WP_000854730.1
Coordinates 1202569..1202946 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P0SQV8
Locus tag APECO2_RS06270 Protein ID WP_001285481.1
Coordinates 1202993..1203367 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APECO2_RS06240 1198603..1198894 + 292 Protein_1123 transposase -
APECO2_RS06245 1198891..1199241 + 351 WP_000624707.1 IS66 family insertion sequence element accessory protein TnpB -
APECO2_RS06250 1199272..1200865 + 1594 Protein_1125 IS66 family transposase -
APECO2_RS06255 1201013..1202001 + 989 Protein_1126 IS630 family transposase -
APECO2_RS06260 1202080..1202572 - 493 Protein_1127 hypothetical protein -
APECO2_RS06265 1202569..1202946 - 378 WP_000854730.1 TA system toxin CbtA family protein Toxin
APECO2_RS06270 1202993..1203367 - 375 WP_001285481.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
APECO2_RS06275 1203417..1204061 - 645 WP_000086759.1 hypothetical protein -
APECO2_RS06280 1204080..1204301 - 222 WP_000692315.1 DUF987 domain-containing protein -
APECO2_RS06285 1204364..1204840 - 477 WP_001313574.1 RadC family protein -
APECO2_RS06290 1204856..1205329 - 474 WP_001313575.1 antirestriction protein -
APECO2_RS06295 1205423..1205668 - 246 WP_001164966.1 hypothetical protein -
APECO2_RS06300 1205668..1206489 - 822 WP_001234359.1 DUF945 domain-containing protein -
APECO2_RS06305 1206589..1206822 - 234 WP_001213776.1 DUF905 family protein -
APECO2_RS06310 1206940..1207392 - 453 WP_000682723.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14212.21 Da        Isoelectric Point: 7.2923

>T45680 WP_000854730.1 NZ_CP006834:c1202946-1202569 [Escherichia coli APEC O2-211]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR

Download         Length: 378 bp

>T45680 NZ_CP006834:c1202946-1202569 [Escherichia coli APEC O2-211]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCTTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CAACTACAGAATGGTGAACGACATCATCCGGGGTGAACATTCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13817.53 Da        Isoelectric Point: 4.7511

>AT45680 WP_001285481.1 NZ_CP006834:c1203367-1202993 [Escherichia coli APEC O2-211]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTIG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT45680 NZ_CP006834:c1203367-1202993 [Escherichia coli APEC O2-211]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCATCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V671

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0SQV8

References