Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3869554..3869912 Replicon chromosome
Accession NZ_CP006830
Organism Escherichia coli APEC O18

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag APECO18_RS27075 Protein ID WP_001332330.1
Coordinates 3869790..3869912 (+) Length 41 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag APECO18_RS19310 Protein ID WP_000125566.1
Coordinates 3869554..3869787 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APECO18_RS19285 3864627..3864914 + 288 WP_000203741.1 ferredoxin-like protein FixX -
APECO18_RS19290 3864973..3866304 + 1332 WP_001183207.1 MFS transporter -
APECO18_RS19295 3866412..3866942 + 531 WP_000600749.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
APECO18_RS19300 3866935..3868797 + 1863 WP_000377122.1 glutathione-regulated potassium-efflux system protein KefC -
APECO18_RS19305 3868989..3869468 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
APECO18_RS19310 3869554..3869787 + 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
APECO18_RS27075 3869790..3869912 + 123 WP_001332330.1 CcdB family protein Toxin
APECO18_RS27080 3869953..3870105 + 153 WP_146692624.1 CcdB family protein -
APECO18_RS19320 3870102..3870950 - 849 WP_000257201.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
APECO18_RS19325 3870957..3871334 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
APECO18_RS19330 3871337..3872158 - 822 WP_001065363.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
APECO18_RS19335 3872155..3873144 - 990 WP_000241229.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
APECO18_RS19340 3873144..3874430 - 1287 WP_000800457.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-39)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 41 a.a.        Molecular weight: 4563.34 Da        Isoelectric Point: 10.9266

>T45671 WP_001332330.1 NZ_CP006830:3869790-3869912 [Escherichia coli APEC O18]
MQFTVYRSRGRNAAFPFVIDVTSDIVGEINRRIVIPLTPI

Download         Length: 123 bp

>T45671 NZ_CP006830:3869790-3869912 [Escherichia coli APEC O18]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTGTTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT45671 WP_000125566.1 NZ_CP006830:3869554-3869787 [Escherichia coli APEC O18]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT45671 NZ_CP006830:3869554-3869787 [Escherichia coli APEC O18]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References