Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1085291..1086122 Replicon chromosome
Accession NZ_CP006830
Organism Escherichia coli APEC O18

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag APECO18_RS05635 Protein ID WP_000854814.1
Coordinates 1085748..1086122 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1PWQ3
Locus tag APECO18_RS05630 Protein ID WP_001285586.1
Coordinates 1085291..1085659 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APECO18_RS05595 1080348..1081418 + 1071 WP_000102631.1 patatin-like phospholipase family protein -
APECO18_RS05600 1081554..1082231 + 678 WP_001362823.1 hypothetical protein -
APECO18_RS05605 1082247..1082657 + 411 WP_000846704.1 hypothetical protein -
APECO18_RS05610 1082878..1083699 + 822 WP_001234570.1 DUF945 domain-containing protein -
APECO18_RS05615 1083962..1084435 + 474 WP_000855074.1 antirestriction protein -
APECO18_RS05620 1084451..1084927 + 477 WP_001351157.1 RadC family protein -
APECO18_RS05625 1084996..1085217 + 222 WP_000692323.1 DUF987 domain-containing protein -
APECO18_RS05630 1085291..1085659 + 369 WP_001285586.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
APECO18_RS05635 1085748..1086122 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
APECO18_RS05640 1086119..1086313 + 195 WP_000988601.1 hypothetical protein -
APECO18_RS26785 1086326..1086439 + 114 WP_001161660.1 DUF957 domain-containing protein -
APECO18_RS25445 1086728..1086874 - 147 Protein_1070 transposase domain-containing protein -
APECO18_RS05650 1086928..1087110 + 183 WP_001016348.1 hypothetical protein -
APECO18_RS05655 1087211..1087540 - 330 WP_000450409.1 DUF496 family protein -
APECO18_RS05660 1087712..1088770 - 1059 WP_001200890.1 FUSC family protein -
APECO18_RS05665 1088968..1089441 - 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
APECO18_RS05670 1089560..1090725 - 1166 Protein_1075 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T45663 WP_000854814.1 NZ_CP006830:1085748-1086122 [Escherichia coli APEC O18]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T45663 NZ_CP006830:1085748-1086122 [Escherichia coli APEC O18]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.41 Da        Isoelectric Point: 5.0468

>AT45663 WP_001285586.1 NZ_CP006830:1085291-1085659 [Escherichia coli APEC O18]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT45663 NZ_CP006830:1085291-1085659 [Escherichia coli APEC O18]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB S1PWQ3

References