Detailed information of TA system TA045649

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 2196607..2197130
• Replicon: chromosome
• Accession: NZ_CP006829
• Organism: Thalassolituus oleivorans R6-15

Toxin (Protein)

• Gene name: parE
• Uniprot ID: W8G9R1
• Locus tag: R615_RS10060
• Protein ID: WP_025265720.1
• Coordinates: 2196607..2196891 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: W8G5L0
• Locus tag: R615_RS10065
• Protein ID: WP_025265721.1
• Coordinates: 2196888..2197130 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
R615_RS10040	2193938..2194732	+	795	WP_025265716.1	uroporphyrinogen-III C-methyltransferase	-
R615_RS10045	2195405..2195821	+	417	WP_025265717.1	GNAT family N-acetyltransferase	-
R615_RS10050	2195943..2196206	+	264	WP_025265718.1	ribbon-helix-helix protein, CopG family	-
R615_RS10055	2196203..2196493	+	291	WP_051482463.1	type II toxin-antitoxin system RelE/ParE family toxin	-
R615_RS10060	2196607..2196891	-	285	WP_025265720.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
R615_RS10065	2196888..2197130	-	243	WP_025265721.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
R615_RS10070	2197219..2197470	-	252	WP_025265722.1	hypothetical protein	-
R615_RS10075	2197668..2197919	+	252	WP_025265723.1	hypothetical protein	-
R615_RS10080	2197979..2198356	+	378	WP_025265724.1	hypothetical protein	-
R615_RS10085	2198353..2198586	+	234	WP_025265725.1	hypothetical protein	-
R615_RS10090	2198867..2199424	+	558	WP_025265726.1	hypothetical protein	-
R615_RS10095	2199532..2200164	-	633	WP_025265727.1	sulfotransferase family protein	-
R615_RS10100	2200266..2200613	-	348	WP_025265728.1	hypothetical protein	-
R615_RS10105	2200692..2201264	-	573	WP_025265729.1	DNA-3-methyladenine glycosylase I	-
R615_RS10110	2201334..2201984	-	651	WP_025265730.1	DUF938 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10806.57 Da
• Isoelectric Point: 9.7129

>T45649 WP_025265720.1 NZ_CP006829:c2196891-2196607 [Thalassolituus oleivorans R6-15]
MTSFTLTTRAKSDLLAIAKFTQVRWGLAQRNIYIKQFDDAFHMLAASPTLGKNCDYIKDGYYKFPQGSHIIFYKFTADGP
LQIIRILHEKMDVA

Nucleotide

• Length: 285 bp

>T45649 NZ_CP006829:c2196891-2196607 [Thalassolituus oleivorans R6-15]
ATGACTTCATTTACGCTAACCACTCGCGCCAAAAGTGATTTGTTAGCTATTGCCAAATTTACGCAAGTTCGCTGGGGGCT
GGCGCAGCGTAATATTTATATCAAGCAGTTTGATGATGCCTTTCATATGCTAGCGGCGTCACCCACCTTAGGAAAAAACT
GTGATTATATTAAAGACGGATATTATAAATTCCCTCAAGGCAGTCACATAATATTCTATAAATTTACAGCAGATGGACCT
TTACAGATTATTCGAATACTTCATGAAAAAATGGATGTAGCTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8924.86 Da
• Isoelectric Point: 4.5023

>AT45649 WP_025265721.1 NZ_CP006829:c2197130-2196888 [Thalassolituus oleivorans R6-15]
MAKNTSMTLGEHFDVFIAHQIESGRYSSASEVIRAGLRALEDHESKLEVLRQMLKDGEASGVAEYSYESFVAELDNENSK

Nucleotide

• Length: 243 bp

>AT45649 NZ_CP006829:c2197130-2196888 [Thalassolituus oleivorans R6-15]
ATGGCTAAAAACACTAGTATGACACTCGGTGAGCACTTTGATGTTTTTATAGCTCATCAGATTGAAAGCGGCCGCTACAG
CTCTGCAAGTGAGGTAATACGCGCAGGTCTGAGGGCACTTGAAGACCACGAAAGTAAGCTCGAAGTATTGCGGCAGATGC
TTAAAGACGGAGAGGCTAGTGGCGTTGCTGAGTATAGTTATGAGTCTTTCGTAGCTGAGCTTGATAATGAAAACAGCAAA
TGA

Structures

Toxin

• AlphaFold DB: W8G9R1

Antitoxin

• AlphaFold DB: W8G5L0