Detailed information of TA system TA045645

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 511384..511898
• Replicon: chromosome
• Accession: NZ_CP006828
• Organism: Ornithobacterium rhinotracheale ORT-UMN 88

Toxin (Protein)

• Gene name: relE
• Uniprot ID: I4A110
• Locus tag: Q785_RS02425
• Protein ID: WP_014791206.1
• Coordinates: 511384..511641 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: I4A109
• Locus tag: Q785_RS02430
• Protein ID: WP_014791205.1
• Coordinates: 511644..511898 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Q785_RS02385	506436..507266	+	831	WP_036601380.1	50S ribosomal protein L11 methyltransferase	-
Q785_RS02390	507270..507563	+	294	WP_014791213.1	ATP-dependent Clp protease adaptor ClpS	-
Q785_RS02395	507578..507991	+	414	WP_155814511.1	Holliday junction resolvase RuvX	-
Q785_RS02400	508142..508714	+	573	WP_014791211.1	peptide deformylase	-
Q785_RS02405	508764..509189	+	426	WP_014791210.1	DUF5606 domain-containing protein	-
Q785_RS02410	509278..510051	+	774	WP_014791209.1	nucleoside triphosphate pyrophosphohydrolase	-
Q785_RS02415	510103..511029	+	927	WP_014791208.1	J domain-containing protein	-
Q785_RS02420	511035..511328	+	294	WP_014791207.1	chaperone modulator CbpM	-
Q785_RS02425	511384..511641	-	258	WP_014791206.1	Txe/YoeB family addiction module toxin	Toxin
Q785_RS02430	511644..511898	-	255	WP_014791205.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
Q785_RS02435	511969..514200	-	2232	WP_014791204.1	TonB-dependent receptor	-
Q785_RS02440	514181..515548	-	1368	WP_014791203.1	HTTM domain-containing protein	-
Q785_RS02445	515575..516702	-	1128	WP_014791202.1	imelysin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10592.16 Da
• Isoelectric Point: 8.4443

>T45645 WP_014791206.1 NZ_CP006828:c511641-511384 [Ornithobacterium rhinotracheale ORT-UMN 88]
MKYIFVDESWEDYLYWQKDDKRKLKRINALLKDISRTPFEGIGKPEPLKHKYSGFWSRRIDDEHCLIYRYEEDKILIAKC
RFHYD

Nucleotide

• Length: 258 bp

>T45645 NZ_CP006828:c511641-511384 [Ornithobacterium rhinotracheale ORT-UMN 88]
ATGAAATATATTTTTGTAGATGAATCTTGGGAAGATTATCTATATTGGCAAAAAGACGATAAACGAAAGCTTAAAAGAAT
CAATGCTTTGTTGAAAGATATTTCGCGCACGCCTTTTGAAGGTATTGGCAAACCTGAGCCATTAAAACATAAATATTCAG
GATTTTGGTCACGCAGAATTGATGATGAACATTGTTTAATTTACCGTTACGAAGAAGATAAAATCCTGATTGCCAAATGT
AGATTTCATTATGATTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9587.97 Da
• Isoelectric Point: 6.3475

>AT45645 WP_014791205.1 NZ_CP006828:c511898-511644 [Ornithobacterium rhinotracheale ORT-UMN 88]
MLVTNISEFRKDLKSYLNKVAKNFETLIINRGKESAIVVLSLDEYNSLMATNYELSSRKNEQRLDAAIAKLKSGESFEKT
LIED

Nucleotide

• Length: 255 bp

>AT45645 NZ_CP006828:c511898-511644 [Ornithobacterium rhinotracheale ORT-UMN 88]
ATGCTAGTTACCAATATTTCAGAATTTAGAAAAGATTTAAAATCCTATTTAAACAAGGTTGCAAAAAACTTTGAAACCTT
AATCATTAATCGTGGAAAAGAATCTGCAATCGTGGTTTTGTCGCTTGATGAGTATAATTCTTTGATGGCGACAAATTATG
AACTGTCTTCTCGCAAAAACGAACAGCGTCTAGATGCTGCAATAGCAAAATTGAAATCAGGAGAATCATTTGAGAAAACA
CTGATTGAAGATTAA

Structures

Toxin

• AlphaFold DB: I4A110

Antitoxin

• AlphaFold DB: I4A109