Detailed information of TA system TA045642

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 1504823..1506011
• Replicon: chromosome
• Accession: NZ_CP006826
• Organism: Helicobacter pylori oki828

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: HPOKI828_RS07275
• Protein ID: WP_025223342.1
• Coordinates: 1504823..1505584 (-)
• Length: 254 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: X2IFS3
• Locus tag: HPOKI828_RS07280
• Protein ID: WP_000245673.1
• Coordinates: 1505574..1506011 (-)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPOKI828_RS07265	1502411..1503571	+	1161	WP_025223340.1	L-seryl-tRNA(Sec) selenium transferase	-
HPOKI828_RS07270	1503659..1504846	+	1188	WP_025223341.1	transcription termination/antitermination protein NusA	-
HPOKI828_RS07275	1504823..1505584	-	762	WP_025223342.1	hypothetical protein	Toxin
HPOKI828_RS07280	1505574..1506011	-	438	WP_000245673.1	SocA family protein	Antitoxin
HPOKI828_RS08535	1506236..1507861	-	1626	Protein_1397	RNA-directed DNA polymerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 254 a.a.
• Molecular weight: 29685.79 Da
• Isoelectric Point: 8.3812

>T45642 WP_025223342.1 NZ_CP006826:c1505584-1504823 [Helicobacter pylori oki828]
METKEEDKDKKLEKIIVLLCEEGDLSSQKDQIIKDLKEIYEGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIRLEDDLNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSKEKKDKQENFFKKPIFWFNLMVTILLIKDSI
SFTEAILILKQRL

Nucleotide

• Length: 762 bp

>T45642 NZ_CP006826:c1505584-1504823 [Helicobacter pylori oki828]
ATGGAAACTAAAGAAGAGGATAAAGATAAAAAGCTAGAAAAAATTATTGTATTGTTGTGCGAAGAGGGGGATTTGTCTAG
CCAAAAAGATCAAATCATCAAAGATCTCAAAGAAATCTATGAAGGAGAATACAAGCATAAATACTCAAAAATCACAACTA
TTATTTTAAATTCCACAAGGGATAAAGAGCAAGCCTTTATGATGCTCACACAAAATATAAAGACACTCAAAGAGATTCAA
GATAATAAGGAAGTTGAAAGCATTAAGCCAAAACTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATCAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATGTTTCTATCAGGTTAGAAGATGATCTAAATAAAAACTATAAAAAAT
TAAGCGAAGAATTGAATAAGCAGCAAACGCAATACATAACAATTTTAGGTATTTTTGCCTCTATTGTTTTAACATTTGTT
GGGGGATTGGCGTTTTCCACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTATCGTTTGGTTTTTGTTATGGCTTT
TATAGCTTTATTTTTTGGGAATATTTTGTATCTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCAAAAGAGAAAAAAG
ATAAACAAGAAAATTTTTTCAAAAAACCTATTTTTTGGTTTAATCTGATGGTTACAATCCTATTGATTAAAGACTCAATA
AGTTTCACAGAAGCAATTTTAATTCTTAAACAAAGACTCTAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17309.47 Da
• Isoelectric Point: 6.7306

>AT45642 WP_000245673.1 NZ_CP006826:c1506011-1505574 [Helicobacter pylori oki828]
MVNALELAKYILKRSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLRKDELETINYSIEKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEVISKDLIKREAKQANGN

Nucleotide

• Length: 438 bp

>AT45642 NZ_CP006826:c1506011-1505574 [Helicobacter pylori oki828]
ATGGTCAATGCTTTGGAACTAGCAAAATATATTCTTAAGCGTTCCAACAAAGAATTGAGCAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATCAAAAAGTTTGACAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAAATATG
GGCCTGTTGCAAGGGAAGTGTATTATGAATATCGCAATTATGGTGCCAATTCCATTGACAAACCCAAAGAAGAAACGCTC
TCACAAAATCTTAGAAAAGATGAATTGGAAACCATCAACTACTCTATAGAAAAATGCAACGAGAAATCCTATTGGGATTT
AGTGAAAGAGAGTCATAAGGAAGATGGTGCTTGGCATAAAAGCTTCAAAGAAGATAGAAAAGAAGTCATTAGCAAAGATT
TGATCAAACGAGAAGCAAAACAAGCAAATGGAAACTAA

Structures

Antitoxin

• AlphaFold DB: X2IFS3