Detailed information of TA system TA045641

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 906912..907482
• Replicon: chromosome
• Accession: NZ_CP006826
• Organism: Helicobacter pylori oki828

Toxin (Protein)

• Gene name: relE
• Uniprot ID: X2IC15
• Locus tag: HPOKI828_RS04340
• Protein ID: WP_025222955.1
• Coordinates: 906912..907184 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HPOKI828_RS04345
• Protein ID: WP_025222956.1
• Coordinates: 907171..907482 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPOKI828_RS04320	903576..904343	-	768	WP_025222953.1	ABC transporter ATP-binding protein	-
HPOKI828_RS04325	904343..905323	-	981	WP_000921481.1	iron ABC transporter permease	-
HPOKI828_RS04330	905316..906164	-	849	WP_025222954.1	SDR family oxidoreductase	-
HPOKI828_RS04335	906305..906829	+	525	WP_001120215.1	acyl-CoA thioesterase	-
HPOKI828_RS04340	906912..907184	-	273	WP_025222955.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HPOKI828_RS04345	907171..907482	-	312	WP_025222956.1	hypothetical protein	Antitoxin
HPOKI828_RS04350	907965..910196	-	2232	WP_025222957.1	Hop family adhesin BabA	-
HPOKI828_RS04370	910716..911237	+	522	WP_025222958.1	hypothetical protein	-
HPOKI828_RS04375	911188..912300	-	1113	WP_025222959.1	hydrogenase formation protein HypD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10598.63 Da
• Isoelectric Point: 9.9378

>T45641 WP_025222955.1 NZ_CP006826:c907184-906912 [Helicobacter pylori oki828]
MLMIETSKKFDKDLKILVKNGFDLKLLYKVVENLAKEQPLDPKYKDHPLKGALKNFRECHLKPDLLLVYQIKKQENTLFL
VRLGSHSELF

Nucleotide

• Length: 273 bp

>T45641 NZ_CP006826:c907184-906912 [Helicobacter pylori oki828]
ATGCTGATGATTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAACGGGTTTGATTTAAAGCTTTT
ATATAAAGTGGTTGAAAATTTAGCCAAAGAGCAACCCCTAGATCCCAAATACAAAGACCACCCGCTCAAAGGCGCTTTAA
AAAATTTTAGGGAATGCCACCTAAAACCGGATTTATTGCTTGTCTATCAAATTAAAAAACAAGAAAACACCCTCTTTTTA
GTAAGACTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 12407.22 Da
• Isoelectric Point: 10.1678

>AT45641 WP_025222956.1 NZ_CP006826:c907482-907171 [Helicobacter pylori oki828]
MPNSPTKKDYTQYSEKQLFNFLNSIKTKQKRALEKLKEIQTQKQRIKKALQFKTLHLTENGYTIEEEREILSRAKDTKNH
LCFKNIEDFKKHCENLRFKNADD

Nucleotide

• Length: 312 bp

>AT45641 NZ_CP006826:c907482-907171 [Helicobacter pylori oki828]
ATGCCTAATTCTCCCACCAAAAAAGACTACACACAATACAGCGAAAAACAGCTTTTTAACTTTCTAAATTCTATCAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAAGAAATCCAAACTCAAAAGCAAAGAATTAAAAAAGCGCTCCAATTTAAAA
CGCTCCATTTAACCGAAAACGGATACACCATAGAAGAAGAGCGAGAAATCTTATCAAGGGCTAAAGACACCAAGAACCAC
CTTTGTTTTAAAAATATAGAGGATTTTAAAAAGCATTGTGAAAACTTAAGATTTAAAAATGCTGATGATTGA

Structures

Toxin

• AlphaFold DB: X2IC15