Detailed information of TA system TA045640

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 1499544..1500753
• Replicon: chromosome
• Accession: NZ_CP006825
• Organism: Helicobacter pylori oki673

Toxin (Protein)

• Gene name: panT
• Uniprot ID: X2ILV7
• Locus tag: HPOKI673_RS07255
• Protein ID: WP_025314210.1
• Coordinates: 1499544..1500326 (-)
• Length: 261 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: X2IFS3
• Locus tag: HPOKI673_RS07260
• Protein ID: WP_000245673.1
• Coordinates: 1500316..1500753 (-)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPOKI673_RS07245	1496882..1498042	+	1161	WP_025314208.1	L-seryl-tRNA(Sec) selenium transferase	-
HPOKI673_RS07250	1498130..1499317	+	1188	WP_025314209.1	transcription termination/antitermination protein NusA	-
HPOKI673_RS07255	1499544..1500326	-	783	WP_025314210.1	hypothetical protein	Toxin
HPOKI673_RS07260	1500316..1500753	-	438	WP_000245673.1	SocA family protein	Antitoxin
HPOKI673_RS08430	1500978..1502602	-	1625	Protein_1390	RNA-directed DNA polymerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 261 a.a.
• Molecular weight: 30638.78 Da
• Isoelectric Point: 9.2968

>T45640 WP_025314210.1 NZ_CP006825:c1500326-1499544 [Helicobacter pylori oki673]
METKEEDKDKKLEKIIVLLCEEGDLSSQKDQIIKDLKEIYEGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIRLEDDLNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSKEKKDKQENFFKKPIFWFNLMVTILFVIGFV
GERIDRQYKAQISKDFKRPR

Nucleotide

• Length: 783 bp

>T45640 NZ_CP006825:c1500326-1499544 [Helicobacter pylori oki673]
ATGGAAACTAAAGAAGAGGATAAAGATAAAAAGCTAGAAAAAATTATTGTATTGTTGTGCGAAGAGGGGGATTTGTCTAG
CCAAAAAGATCAAATCATCAAAGATCTCAAAGAAATCTATGAAGGAGAATACAAGCATAAATACTCAAAAATCACAACTA
TTATTTTAAATTCCACAAGGGATAAAGAGCAAGCCTTTATGATGCTCACACAAAATATAAAGACACTCAAAGAGATTCAA
GATAATAAGGAAGTTGAAAGCATTAAGCCAAAACTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATCAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATGTTTCTATCAGGTTAGAAGATGATCTAAATAAAAACTATAAAAAAT
TAAGCGAAGAATTGAATAAGCAGCAAACGCAATACATAACAATTTTAGGTATTTTTGCCTCTATTGTTTTAACATTTGTT
GGGGGATTGGCGTTTTCCACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTATCGTTTGGTTTTTGTTATGGCTTT
TATAGCTTTATTTTTTGGGAATATTTTGTATCTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCAAAAGAGAAAAAAG
ATAAACAAGAAAATTTTTTCAAAAAACCTATTTTTTGGTTTAATCTGATGGTTACAATCCTATTTGTGATTGGTTTTGTG
GGAGAGAGAATTGATAGGCAATATAAAGCTCAGATTTCTAAAGATTTTAAAAGACCAAGATAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17309.47 Da
• Isoelectric Point: 6.7306

>AT45640 WP_000245673.1 NZ_CP006825:c1500753-1500316 [Helicobacter pylori oki673]
MVNALELAKYILKRSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLRKDELETINYSIEKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEVISKDLIKREAKQANGN

Nucleotide

• Length: 438 bp

>AT45640 NZ_CP006825:c1500753-1500316 [Helicobacter pylori oki673]
ATGGTCAATGCTTTGGAACTAGCAAAATATATTCTTAAGCGTTCCAACAAAGAATTGAGCAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATCAAAAAGTTTGACAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAAATATG
GGCCTGTTGCAAGGGAAGTGTATTATGAATATCGCAATTATGGTGCCAATTCCATTGACAAACCCAAAGAAGAAACGCTC
TCACAAAATCTTAGAAAAGATGAATTGGAAACCATCAACTACTCTATAGAAAAATGCAACGAGAAATCCTATTGGGATTT
AGTGAAAGAGAGTCATAAGGAAGATGGTGCTTGGCATAAAAGCTTCAAAGAAGATAGAAAAGAAGTCATTAGCAAAGATT
TGATCAAACGAGAAGCAAAACAAGCAAATGGAAACTAA

Structures

Toxin

• AlphaFold DB: X2ILV7

Antitoxin

• AlphaFold DB: X2IFS3