Detailed information of TA system TA045639

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 902441..903011
• Replicon: chromosome
• Accession: NZ_CP006825
• Organism: Helicobacter pylori oki673

Toxin (Protein)

• Gene name: relE
• Uniprot ID: X2IC15
• Locus tag: HPOKI673_RS04335
• Protein ID: WP_025222955.1
• Coordinates: 902441..902713 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: X2IKC6
• Locus tag: HPOKI673_RS04340
• Protein ID: WP_001133858.1
• Coordinates: 902700..903011 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPOKI673_RS04315	899105..899872	-	768	WP_025313942.1	ABC transporter ATP-binding protein	-
HPOKI673_RS04320	899872..900852	-	981	WP_000921481.1	iron ABC transporter permease	-
HPOKI673_RS04325	900845..901693	-	849	WP_025313943.1	SDR family oxidoreductase	-
HPOKI673_RS04330	901834..902358	+	525	WP_001120215.1	acyl-CoA thioesterase	-
HPOKI673_RS04335	902441..902713	-	273	WP_025222955.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HPOKI673_RS04340	902700..903011	-	312	WP_001133858.1	hypothetical protein	Antitoxin
HPOKI673_RS04345	903522..905675	-	2154	WP_038419162.1	Hop family adhesin BabA	-
HPOKI673_RS04360	906246..906767	+	522	WP_025313945.1	hypothetical protein	-
HPOKI673_RS04365	906718..907830	-	1113	WP_025222959.1	hydrogenase formation protein HypD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10598.63 Da
• Isoelectric Point: 9.9378

>T45639 WP_025222955.1 NZ_CP006825:c902713-902441 [Helicobacter pylori oki673]
MLMIETSKKFDKDLKILVKNGFDLKLLYKVVENLAKEQPLDPKYKDHPLKGALKNFRECHLKPDLLLVYQIKKQENTLFL
VRLGSHSELF

Nucleotide

• Length: 273 bp

>T45639 NZ_CP006825:c902713-902441 [Helicobacter pylori oki673]
ATGCTGATGATTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAACGGGTTTGATTTAAAGCTTTT
ATATAAAGTGGTTGAAAATTTAGCCAAAGAGCAACCCCTAGATCCCAAATACAAAGACCACCCGCTCAAAGGCGCTTTAA
AAAATTTTAGGGAATGCCACCTAAAACCGGATTTATTGCTTGTCTATCAAATTAAAAAACAAGAAAACACCCTCTTTTTA
GTAAGACTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 12290.11 Da
• Isoelectric Point: 10.1678

>AT45639 WP_001133858.1 NZ_CP006825:c903011-902700 [Helicobacter pylori oki673]
MPNSPTKKDYTQYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNH
LCFKSVEDFKKHCENLRFKNADD

Nucleotide

• Length: 312 bp

>AT45639 NZ_CP006825:c903011-902700 [Helicobacter pylori oki673]
ATGCCTAACTCTCCCACCAAAAAAGACTACACGCAATACAGCGAAAAACAGCTTTTTAACTTTCTAAATTCTATCAAGAC
CAAACAAAAAAGAGCACTAGAAAAATTGAAAGAAATCCAAGCTCAAAAACAAAGAATTAAAAAAGCCCTCCAATTTAAAG
CGCTCCATTTAACCGAAAACGGATACACCATAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAAGACACCAAGAACCAC
CTTTGTTTTAAAAGCGTAGAGGATTTTAAAAAGCATTGTGAAAACTTAAGATTTAAAAATGCTGATGATTGA

Structures

Toxin

• AlphaFold DB: X2IC15

Antitoxin

• AlphaFold DB: X2IKC6