Detailed information of TA system TA045638

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 1531267..1532458
• Replicon: chromosome
• Accession: NZ_CP006824
• Organism: Helicobacter pylori oki422

Toxin (Protein)

• Gene name: panT
• Uniprot ID: X2I069
• Locus tag: HPOKI422_RS07400
• Protein ID: WP_025276463.1
• Coordinates: 1531267..1532031 (-)
• Length: 255 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: X2HUE6
• Locus tag: HPOKI422_RS07405
• Protein ID: WP_025276464.1
• Coordinates: 1532021..1532458 (-)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPOKI422_RS07390	1528585..1529757	+	1173	WP_025277196.1	L-seryl-tRNA(Sec) selenium transferase	-
HPOKI422_RS07395	1529853..1531040	+	1188	WP_025276462.1	transcription termination/antitermination protein NusA	-
HPOKI422_RS07400	1531267..1532031	-	765	WP_025276463.1	hypothetical protein	Toxin
HPOKI422_RS07405	1532021..1532458	-	438	WP_025276464.1	SocA family protein	Antitoxin
HPOKI422_RS07410	1532685..1534308	-	1624	Protein_1397	RNA-directed DNA polymerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 255 a.a.
• Molecular weight: 29684.70 Da
• Isoelectric Point: 7.6840

>T45638 WP_025276463.1 NZ_CP006824:c1532031-1531267 [Helicobacter pylori oki422]
METKEEDKDKKLEEIIVSLCEKGDLSSQTDQIIKDLKEIYEGEYRHKYSKITTIILNSTRDKEQAFMTLAQNIRTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIKLEKDLNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
AGLAFSTSVLSNIDKANAYRLVFVMAFMALFFGNILYLLFSFLSKISLSKEEKDKQENFCKKPIFWFNLIVTILLVIGFC
GELHIIQRLVSKYL

Nucleotide

• Length: 765 bp

>T45638 NZ_CP006824:c1532031-1531267 [Helicobacter pylori oki422]
ATGGAAACTAAAGAAGAAGATAAAGATAAAAAGCTAGAAGAAATTATTGTATCGCTGTGCGAAAAGGGGGATTTGTCTAG
CCAAACAGATCAAATCATCAAAGATCTCAAAGAAATCTATGAAGGAGAATACAGGCATAAATACTCAAAAATTACAACTA
TTATTTTAAATTCTACAAGGGATAAAGAGCAAGCCTTTATGACGCTCGCACAAAATATAAGGACACTCAAAGAGATTCAA
GATAATAAAGAAGTTGAAAGCATTAAACCAAAACTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATCAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATGTTTCTATAAAGTTAGAAAAAGATCTAAATAAAAACTATAAAAAAT
TAAGCGAAGAATTGAATAAGCAACAAACGCAATACATAACCATTTTAGGTATTTTTGCTTCTATTGTTTTAACATTTGTT
GCGGGATTAGCGTTTTCCACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTACCGTTTGGTTTTTGTTATGGCTTT
TATGGCTTTATTTTTTGGGAATATTTTGTATCTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCAAAAGAGGAAAAAG
ATAAACAAGAAAATTTTTGCAAAAAACCTATTTTTTGGTTTAATTTAATAGTTACAATTCTACTTGTGATTGGTTTTTGT
GGAGAATTGCATATAATACAGAGATTAGTTTCTAAATATCTTTAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17216.40 Da
• Isoelectric Point: 6.8670

>AT45638 WP_025276464.1 NZ_CP006824:c1532458-1532021 [Helicobacter pylori oki422]
MVNALELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWRYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLRKDELETINCSIEKCSKKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIKQEAKQANGN

Nucleotide

• Length: 438 bp

>AT45638 NZ_CP006824:c1532458-1532021 [Helicobacter pylori oki422]
ATGGTTAATGCTTTGGAACTAGCAAAATATATTCTTAAGCATTCAAACAAAGAATTGAGTAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATCAAAAAGTTTGACAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAGATACG
GGCCTGTTGCAAGAGAAGTGTATTATGAATACCGCAATTATGGTGCCAATTCCATTGACAAACCCAAAGAAGAAACGCTC
TCACAAAATCTTAGAAAAGATGAACTTGAAACCATCAATTGCTCCATAGAAAAATGCAGCAAAAAATCTTATTGGGATTT
AGTGAAAGAGAGTCATAAAGAAGATGGCGCTTGGCATAAAAGCTTCAAAGAAGATAGAAAAGAAATCATTAGCAAAGATT
TGATCAAACAAGAAGCCAAACAAGCAAATGGAAACTAA

Structures

Toxin

• AlphaFold DB: X2I069

Antitoxin

• AlphaFold DB: X2HUE6