Detailed information of TA system TA045636

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 1504176..1505385
• Replicon: chromosome
• Accession: NZ_CP006823
• Organism: Helicobacter pylori oki154

Toxin (Protein)

• Gene name: panT
• Uniprot ID: X2ILV7
• Locus tag: HPOKI154_RS07300
• Protein ID: WP_025314210.1
• Coordinates: 1504176..1504958 (-)
• Length: 261 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: HPOKI154_RS07305
• Protein ID: WP_025367086.1
• Coordinates: 1504948..1505385 (-)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPOKI154_RS07290	1501514..1502674	+	1161	WP_025367084.1	L-seryl-tRNA(Sec) selenium transferase	-
HPOKI154_RS07295	1502762..1503949	+	1188	WP_025367085.1	transcription termination/antitermination protein NusA	-
HPOKI154_RS07300	1504176..1504958	-	783	WP_025314210.1	hypothetical protein	Toxin
HPOKI154_RS07305	1504948..1505385	-	438	WP_025367086.1	SocA family protein	Antitoxin
HPOKI154_RS08495	1505610..1507224	-	1615	Protein_1395	RNA-directed DNA polymerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 261 a.a.
• Molecular weight: 30638.78 Da
• Isoelectric Point: 9.2968

>T45636 WP_025314210.1 NZ_CP006823:c1504958-1504176 [Helicobacter pylori oki154]
METKEEDKDKKLEKIIVLLCEEGDLSSQKDQIIKDLKEIYEGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIRLEDDLNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSKEKKDKQENFFKKPIFWFNLMVTILFVIGFV
GERIDRQYKAQISKDFKRPR

Nucleotide

• Length: 783 bp

>T45636 NZ_CP006823:c1504958-1504176 [Helicobacter pylori oki154]
ATGGAAACTAAAGAAGAGGATAAAGATAAAAAGCTAGAAAAAATTATTGTATTGTTGTGCGAAGAGGGGGATTTGTCTAG
CCAAAAAGATCAAATCATCAAAGATCTCAAAGAAATCTATGAAGGAGAATACAAGCATAAATACTCAAAAATCACAACTA
TTATTTTAAATTCCACAAGGGATAAAGAGCAAGCCTTTATGATGCTCACACAAAATATAAAGACACTCAAAGAGATTCAA
GATAATAAGGAAGTTGAAAGCATTAAGCCAAAACTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATCAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATGTTTCTATCAGGTTAGAAGATGATCTAAATAAAAACTATAAAAAAT
TAAGCGAAGAATTGAATAAGCAGCAAACGCAATACATAACAATTTTAGGTATTTTTGCCTCTATTGTTTTAACATTTGTT
GGGGGATTGGCGTTTTCCACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTATCGTTTGGTTTTTGTTATGGCTTT
TATAGCTTTATTTTTTGGGAATATTTTGTATCTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCAAAAGAGAAAAAAG
ATAAACAAGAAAATTTTTTCAAAAAACCTATTTTTTGGTTTAATCTGATGGTTACAATCCTATTTGTGATTGGTTTTGTG
GGAGAGAGAATTGATAGGCAATATAAAGCTCAGATTTCTAAAGATTTTAAAAGACCAAGATAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17248.45 Da
• Isoelectric Point: 7.2410

>AT45636 WP_025367086.1 NZ_CP006823:c1505385-1504948 [Helicobacter pylori oki154]
MVNALELAKYILKRSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLREDELKTINCSIQKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEVISKDLIKREAKQANGN

Nucleotide

• Length: 438 bp

>AT45636 NZ_CP006823:c1505385-1504948 [Helicobacter pylori oki154]
ATGGTCAATGCTTTGGAACTAGCAAAATATATTCTTAAGCGTTCCAACAAAGAATTGAGCAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATCAAAAAGTTTGACAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAAATACG
GACCTGTTGCAAGAGAAGTGTATTATGAATATCGCAATTATGGTGCCAATTCTATTGACAAACCCAAAGAAGAAACGCTC
TCACAAAATCTTAGAGAAGATGAACTTAAAACCATCAATTGCTCCATACAAAAATGCAACGAAAAATCCTATTGGGATTT
AGTGAAAGAGAGTCATAAAGAAGATGGCGCTTGGCATAAAAGCTTCAAAGAAGATAGAAAAGAAGTCATTAGCAAAGATT
TGATCAAACGAGAAGCAAAACAAGCAAATGGAAACTAA

Structures

Toxin

• AlphaFold DB: X2ILV7