Detailed information of TA system TA045634

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 859759..860329
• Replicon: chromosome
• Accession: NZ_CP006822
• Organism: Helicobacter pylori oki128

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HPOKI128_RS04150
• Protein ID: WP_025288270.1
• Coordinates: 859759..860031 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M4ZPF7
• Locus tag: HPOKI128_RS04155
• Protein ID: WP_015429139.1
• Coordinates: 860018..860329 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPOKI128_RS04130	856423..857190	-	768	WP_025288268.1	ABC transporter ATP-binding protein	-
HPOKI128_RS04135	857190..858170	-	981	WP_000921481.1	iron ABC transporter permease	-
HPOKI128_RS04140	858163..859011	-	849	WP_025288269.1	SDR family oxidoreductase	-
HPOKI128_RS04145	859152..859676	+	525	WP_001120215.1	acyl-CoA thioesterase	-
HPOKI128_RS04150	859759..860031	-	273	WP_025288270.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HPOKI128_RS04155	860018..860329	-	312	WP_015429139.1	hypothetical protein	Antitoxin
HPOKI128_RS04160	860847..863078	-	2232	WP_025288271.1	Hop family adhesin BabA	-
HPOKI128_RS04180	863612..864133	+	522	WP_025222958.1	hypothetical protein	-
HPOKI128_RS04185	864084..865196	-	1113	WP_025222959.1	hydrogenase formation protein HypD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10614.63 Da
• Isoelectric Point: 9.9378

>T45634 WP_025288270.1 NZ_CP006822:c860031-859759 [Helicobacter pylori oki128]
MLMVETSKKFDKDLKILVKNGFDLKLLYKVVENLAKEQPLDPKYKDHPLKGTLKNFRECHLKPDLLLVYQIKKQENTLFL
VRLGSHSELF

Nucleotide

• Length: 273 bp

>T45634 NZ_CP006822:c860031-859759 [Helicobacter pylori oki128]
ATGCTGATGGTTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAACGGGTTTGATTTAAAGCTTTT
ATATAAAGTGGTTGAAAATTTAGCCAAAGAGCAACCCTTAGATCCTAAATACAAAGACCACCCGCTCAAAGGCACTTTAA
AAAATTTTAGGGAATGCCACCTAAAACCGGATTTATTGCTTGTCTATCAAATTAAAAAACAAGAAAACACCCTCTTTTTA
GTAAGACTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 12232.07 Da
• Isoelectric Point: 10.2825

>AT45634 WP_015429139.1 NZ_CP006822:c860329-860018 [Helicobacter pylori oki128]
MPNSPTKKDYTQYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNH
LCFKSVEDFKKHCENLRFKNADG

Nucleotide

• Length: 312 bp

>AT45634 NZ_CP006822:c860329-860018 [Helicobacter pylori oki128]
ATGCCTAACTCTCCCACCAAAAAAGACTACACGCAATACAGCGAAAAACAGCTTTTTAACTTTCTAAATTCTATCAAGAC
CAAACAAAAAAGAGCACTAGAAAAATTGAAAGAAATCCAAGCTCAAAAACAAAGAATTAAAAAAGCCCTCCAATTTAAAG
CGCTCCATTTAACCGAAAACGGATACACCATAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAAGACACCAAGAACCAC
CTTTGTTTTAAAAGCGTAGAGGATTTTAAAAAGCATTGTGAAAACTTAAGATTTAAAAATGCTGATGGTTGA

Structures

Antitoxin

• AlphaFold DB: M4ZPF7