Detailed information of TA system TA045633

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 1535144..1536335
• Replicon: chromosome
• Accession: NZ_CP006821
• Organism: Helicobacter pylori oki112

Toxin (Protein)

• Gene name: panT
• Uniprot ID: X2I069
• Locus tag: HPOKI112_RS07400
• Protein ID: WP_025276463.1
• Coordinates: 1535144..1535908 (-)
• Length: 255 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: X2HUE6
• Locus tag: HPOKI112_RS07405
• Protein ID: WP_025276464.1
• Coordinates: 1535898..1536335 (-)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPOKI112_RS07390	1532462..1533634	+	1173	WP_025277196.1	L-seryl-tRNA(Sec) selenium transferase	-
HPOKI112_RS07395	1533730..1534917	+	1188	WP_025310049.1	transcription termination/antitermination protein NusA	-
HPOKI112_RS07400	1535144..1535908	-	765	WP_025276463.1	hypothetical protein	Toxin
HPOKI112_RS07405	1535898..1536335	-	438	WP_025276464.1	SocA family protein	Antitoxin
HPOKI112_RS07410	1536562..1538185	-	1624	Protein_1412	RNA-directed DNA polymerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 255 a.a.
• Molecular weight: 29684.70 Da
• Isoelectric Point: 7.6840

>T45633 WP_025276463.1 NZ_CP006821:c1535908-1535144 [Helicobacter pylori oki112]
METKEEDKDKKLEEIIVSLCEKGDLSSQTDQIIKDLKEIYEGEYRHKYSKITTIILNSTRDKEQAFMTLAQNIRTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIKLEKDLNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
AGLAFSTSVLSNIDKANAYRLVFVMAFMALFFGNILYLLFSFLSKISLSKEEKDKQENFCKKPIFWFNLIVTILLVIGFC
GELHIIQRLVSKYL

Nucleotide

• Length: 765 bp

>T45633 NZ_CP006821:c1535908-1535144 [Helicobacter pylori oki112]
ATGGAAACTAAAGAAGAAGATAAAGATAAAAAGCTAGAAGAAATTATTGTATCGCTGTGCGAAAAGGGGGATTTGTCTAG
CCAAACAGATCAAATCATCAAAGATCTCAAAGAAATCTATGAAGGAGAATACAGGCATAAATACTCAAAAATTACAACTA
TTATTTTAAATTCTACAAGGGATAAAGAGCAAGCCTTTATGACGCTCGCACAAAATATAAGGACACTCAAAGAGATTCAA
GATAATAAAGAAGTTGAAAGCATTAAACCAAAACTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATCAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATGTTTCTATAAAGTTAGAAAAAGATCTAAATAAAAACTATAAAAAAT
TAAGCGAAGAATTGAATAAGCAACAAACGCAATACATAACCATTTTAGGTATTTTTGCTTCTATTGTTTTAACATTTGTT
GCGGGATTAGCGTTTTCCACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTACCGTTTGGTTTTTGTTATGGCTTT
TATGGCTTTATTTTTTGGGAATATTTTGTATCTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCAAAAGAGGAAAAAG
ATAAACAAGAAAATTTTTGCAAAAAACCTATTTTTTGGTTTAATTTAATAGTTACAATTCTACTTGTGATTGGTTTTTGT
GGAGAATTGCATATAATACAGAGATTAGTTTCTAAATATCTTTAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17216.40 Da
• Isoelectric Point: 6.8670

>AT45633 WP_025276464.1 NZ_CP006821:c1536335-1535898 [Helicobacter pylori oki112]
MVNALELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWRYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLRKDELETINCSIEKCSKKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIKQEAKQANGN

Nucleotide

• Length: 438 bp

>AT45633 NZ_CP006821:c1536335-1535898 [Helicobacter pylori oki112]
ATGGTTAATGCTTTGGAACTAGCAAAATATATTCTTAAGCATTCAAACAAAGAATTGAGTAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATCAAAAAGTTTGACAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAGATACG
GGCCTGTTGCAAGAGAAGTGTATTATGAATACCGCAATTATGGTGCCAATTCCATTGACAAACCCAAAGAAGAAACGCTC
TCACAAAATCTTAGAAAAGATGAACTTGAAACCATCAATTGCTCCATAGAAAAATGCAGCAAAAAATCTTATTGGGATTT
AGTGAAAGAGAGTCATAAAGAAGACGGTGCTTGGCATAAAAGCTTCAAAGAAGATAGAAAAGAAATCATTAGCAAAGATT
TGATCAAACAAGAAGCCAAACAAGCAAATGGAAACTAA

Structures

Toxin

• AlphaFold DB: X2I069

Antitoxin

• AlphaFold DB: X2HUE6