Detailed information of TA system TA045631

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 955118..955793
• Replicon: chromosome
• Accession: NZ_CP006821
• Organism: Helicobacter pylori oki112

Toxin (Protein)

• Gene name: relE
• Uniprot ID: X2HYP8
• Locus tag: HPOKI112_RS04510
• Protein ID: WP_025309849.1
• Coordinates: 955118..955435 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: X2HT18
• Locus tag: HPOKI112_RS04515
• Protein ID: WP_025309850.1
• Coordinates: 955416..955793 (-)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPOKI112_RS04485	950427..951500	-	1074	WP_200867684.1	glycosyltransferase family 8 protein	-
HPOKI112_RS08250	951606..951713	-	108	Protein_864	iron ABC transporter ATP-binding protein	-
HPOKI112_RS04490	951799..952566	-	768	WP_025309845.1	ABC transporter ATP-binding protein	-
HPOKI112_RS04495	952566..953546	-	981	WP_025309846.1	iron ABC transporter permease	-
HPOKI112_RS04500	953539..954381	-	843	WP_025309847.1	SDR family oxidoreductase	-
HPOKI112_RS04505	954521..955045	+	525	WP_025309848.1	acyl-CoA thioesterase	-
HPOKI112_RS04510	955118..955435	-	318	WP_025309849.1	type II toxin-antitoxin system YafQ family toxin	Toxin
HPOKI112_RS04515	955416..955793	-	378	WP_025309850.1	hypothetical protein	Antitoxin
HPOKI112_RS04525	956334..958550	-	2217	WP_025309852.1	Hop family adhesin BabA	-
HPOKI112_RS04545	958963..959580	+	618	Protein_872	hypothetical protein	-
HPOKI112_RS04550	959531..960643	-	1113	WP_025309855.1	hydrogenase formation protein HypD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (53-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12278.41 Da
• Isoelectric Point: 9.8663

>T45631 WP_025309849.1 NZ_CP006821:c955435-955118 [Helicobacter pylori oki112]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFQDHALKGKKKEPLDPQFKDHALKGNWKPFRECHIKA
DILLVYLVRDDELILVRLGSHSELF

Nucleotide

• Length: 318 bp

>T45631 NZ_CP006821:c955435-955118 [Helicobacter pylori oki112]
GTGTTGAAACTCAACCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATAAGGTCATTCTGTCTTTGAGAAAGAAAGAACCGCTAGACCCACAATTTCAAGATCATGCTTTAAAAGGCAAAAAGA
AAGAACCGCTAGACCCACAATTTAAAGATCATGCTTTAAAAGGCAATTGGAAACCTTTTAGGGAATGCCACATCAAAGCT
GATATTTTGCTTGTGTATTTAGTGAGAGATGATGAGCTTATTTTAGTAAGGTTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14791.76 Da
• Isoelectric Point: 7.8121

>AT45631 WP_025309850.1 NZ_CP006821:c955793-955416 [Helicobacter pylori oki112]
MPNSPTKKDYTQYSEKQLFNLIHQLERKIKKMQNNRASFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GYEIPNIQTQQAMRDALNKETDLIIEDFSSYSDERKRALGVETQP

Nucleotide

• Length: 378 bp

>AT45631 NZ_CP006821:c955793-955416 [Helicobacter pylori oki112]
ATGCCTAATTCTCCCACCAAAAAAGACTACACACAATACAGCGAAAAACAGCTTTTTAATTTAATCCATCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATAATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGTATGAGATCCCAAACATTCAAACGCAACAAGCCATGAGAGATGCGCTTAACAAAGAAACCGATTTGATTATTGAGGA
TTTTTCTAGTTATAGCGATGAAAGAAAAAGGGCGTTAGGTGTTGAAACTCAACCTTAA

Structures

Toxin

• AlphaFold DB: X2HYP8

Antitoxin

• AlphaFold DB: X2HT18