Detailed information of TA system TA045627

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 949046..949596
• Replicon: chromosome
• Accession: NZ_CP006820
• Organism: Helicobacter pylori oki102

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HPOKI102_RS04480
• Protein ID: WP_025276083.1
• Coordinates: 949336..949596 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HPOKI102_RS04475
• Protein ID: WP_038420580.1
• Coordinates: 949046..949303 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPOKI102_RS08265	945032..945139	-	108	Protein_854	iron ABC transporter ATP-binding protein	-
HPOKI102_RS04445	945226..945993	-	768	WP_000242353.1	ABC transporter ATP-binding protein	-
HPOKI102_RS04450	945993..946973	-	981	WP_000921438.1	iron ABC transporter permease	-
HPOKI102_RS04455	946966..947814	-	849	WP_025276079.1	SDR family oxidoreductase	-
HPOKI102_RS04460	947954..948478	+	525	WP_001135603.1	acyl-CoA thioesterase	-
HPOKI102_RS04470	948677..949032	-	356	Protein_859	YafQ family addiction module toxin	-
HPOKI102_RS04475	949046..949303	-	258	WP_038420580.1	hypothetical protein	Antitoxin
HPOKI102_RS04480	949336..949596	-	261	WP_025276083.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HPOKI102_RS04485	949577..949954	-	378	WP_025276084.1	hypothetical protein	-
HPOKI102_RS04490	950468..952690	-	2223	WP_025276085.1	Hop family adhesin BabA	-
HPOKI102_RS04505	953200..953721	+	522	WP_038420644.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10065.78 Da
• Isoelectric Point: 8.0618

>T45627 WP_025276083.1 NZ_CP006820:c949596-949336 [Helicobacter pylori oki102]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVILRKKESLSPQFQDHALKGKWKPFRECHIKADILLVYLVQDDELILVRLG
SHSELF

Nucleotide

• Length: 261 bp

>T45627 NZ_CP006820:c949596-949336 [Helicobacter pylori oki102]
GTGTTGAAACTCAACCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATGAAGTCATTCTAAGAAAGAAAGAATCATTATCCCCACAATTTCAAGATCATGCCTTAAAGGGAAAGTGGAAACCTT
TTAGGGAATGCCACATCAAAGCCGATATTTTGCTTGTGTATTTAGTGCAAGATGATGAGCTGATTTTAGTAAGGTTAGGC
AGTCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10003.71 Da
• Isoelectric Point: 10.1124

>AT45627 WP_038420580.1 NZ_CP006820:c949303-949046 [Helicobacter pylori oki102]
IACTKQLVNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALNLTENGYTIEEEQEILVRAKDTKNHLCFKSIEDFKK
HCENL

Nucleotide

• Length: 258 bp

>AT45627 NZ_CP006820:c949303-949046 [Helicobacter pylori oki102]
ATCGCTTGCACTAAACAGCTTGTTAACTTTTTGAATTCTATCAAGACCAAACAAAAAAGAGCGTTAGAAAAATTGAAGGA
AATCCAAGCTCAAAAACAAAGAATCAAAAAAGCGCTCCAATTTAAAGCGCTAAACCTAACCGAAAATGGATACACCATAG
AAGAAGAGCAAGAAATCTTAGTAAGGGCTAAAGATACCAAGAACCACCTTTGTTTTAAAAGCATAGAGGATTTTAAGAAG
CATTGTGAAAACTTATAA