45620

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 74659..75410 Replicon plasmid p1
Accession NZ_CP006799
Organism Klebsiella pneumoniae subsp. pneumoniae PittNDM01

Toxin (Protein)


Gene name ataT Uniprot ID H6U1U8
Locus tag Q770_RS26560 Protein ID WP_014386536.1
Coordinates 74659..75141 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag Q770_RS26565 Protein ID WP_004902250.1
Coordinates 75132..75410 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Q770_RS26535 71058..71705 - 648 WP_014386537.1 EcsC family protein -
Q770_RS26540 71732..72487 - 756 WP_004902235.1 DUF2971 domain-containing protein -
Q770_RS26545 72588..72980 - 393 WP_032442757.1 hypothetical protein -
Q770_RS26550 73085..73624 - 540 WP_004902239.1 hypothetical protein -
Q770_RS26560 74659..75141 - 483 WP_014386536.1 GNAT family N-acetyltransferase Toxin
Q770_RS26565 75132..75410 - 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
Q770_RS26570 75529..75741 - 213 WP_004902255.1 hypothetical protein -
Q770_RS26575 75849..76190 - 342 WP_004902257.1 hypothetical protein -
Q770_RS26585 77020..77478 - 459 WP_014386535.1 hypothetical protein -
Q770_RS26590 78131..78586 - 456 WP_001166628.1 Hg(II)-responsive transcriptional regulator -
Q770_RS26595 78658..79023 + 366 WP_004200999.1 mercuric ion transporter MerT -
Q770_RS26600 79039..79314 + 276 WP_043907009.1 mercury resistance system periplasmic binding protein MerP -
Q770_RS26605 79342..79767 + 426 WP_000522996.1 organomercurial transporter MerC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(3')-VI / blaNDM-1 / qnrB1 / aac(6')-Ib-cr / blaOXA-1 / dfrA14 / dfrA12 / aadA2 / qacE / sul1 / armA / msr(E) / mph(E) - 1..283371 283371


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17662.45 Da        Isoelectric Point: 8.9130

>T45620 WP_014386536.1 NZ_CP006799:c75141-74659 [Klebsiella pneumoniae subsp. pneumoniae PittNDM01]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

>T45620 NZ_CP006799:c75141-74659 [Klebsiella pneumoniae subsp. pneumoniae PittNDM01]
ATGGGAATGAGAGCGCCTGAATCCCTGACGGCTGAACATAACATCGCTGAGTTCTGCTGCCAGGAGCCTGCCCTTAATGA
GTGGTTAAAGAAGAAGGCTCTCAGAAACCACAGTACCGGCATTTCCCGTGTCTATGTCGTCTGCGCAGAAAACACTAACC
GGGTCATCGGTTATTATTGTTTATCTTCGGGTAGCGTCCACCGTAACACAGTGCCTGGGGCCTATAGACGCAACGCGCCT
GATGTCATTCCAGTCATTGTTTTGGGACGGCTTGCCATCGACCAGGCCTGGGCCGGGAATGGGCTTGGTGCCGCACTTCT
TAAGGATGCTATATACCGTACGCAAAACATAGCCTTTCAGGTCGGGGTGAGAGCACTGGCCGTGCATGCGCTGAATGAAG
AAGTTAAATGTTTTTACACCCGTTTTGGCTTTGAGCCTTCCATAGTCAACACGCTGACATTGTTATTCCCGATAAAAGTC
TGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT45620 WP_004902250.1 NZ_CP006799:c75410-75132 [Klebsiella pneumoniae subsp. pneumoniae PittNDM01]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp

>AT45620 NZ_CP006799:c75410-75132 [Klebsiella pneumoniae subsp. pneumoniae PittNDM01]
ATGAAACCAGACGTTCGTGAAGCTCCGATTAATATCCGGGCCAAAACATCACAGCGTGACCTGATCGACATGGCCGCAAG
CCTGGTCTCAAAATCACGGACTGATTTTATGCTTGAGGTTGCCTGCAGGGAGGCACAGGACATTCTGCTTGATCAACGCC
TGTTCCTCCTCAATGACAATCAGTTTGAGGCGTTTATTGAAGAGCTTGACGCCCCAATAACGCCGGAGCGCCAGGCGCGA
ATCGATAACCTGATGAACCGCAAATCACCATGGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBI1

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References