Detailed information of TA system TA045619

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4411333..4411990
• Replicon: chromosome
• Accession: NZ_CP006798
• Organism: Klebsiella pneumoniae subsp. pneumoniae PittNDM01

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: Q770_RS21580
• Protein ID: WP_004181233.1
• Coordinates: 4411580..4411990 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: Q770_RS21575
• Protein ID: WP_002916312.1
• Coordinates: 4411333..4411599 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Q770_RS21550	4406489..4407922	-	1434	WP_004181234.1	6-phospho-beta-glucosidase	-
Q770_RS21555	4408041..4408769	-	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
Q770_RS21560	4408819..4409130	+	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
Q770_RS21565	4409294..4409953	+	660	WP_002916317.1	hemolysin III family protein	-
Q770_RS21570	4410104..4411087	-	984	WP_002916313.1	tRNA-modifying protein YgfZ	-
Q770_RS21575	4411333..4411599	+	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
Q770_RS21580	4411580..4411990	+	411	WP_004181233.1	protein YgfX	Toxin
Q770_RS21585	4411997..4412518	-	522	WP_004144730.1	flavodoxin FldB	-
Q770_RS21590	4412619..4413515	+	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
Q770_RS21595	4413538..4414251	+	714	WP_002916301.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
Q770_RS21600	4414257..4415990	+	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16121.92 Da
• Isoelectric Point: 11.1565

>T45619 WP_004181233.1 NZ_CP006798:4411580-4411990 [Klebsiella pneumoniae subsp. pneumoniae PittNDM01]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAEEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T45619 NZ_CP006798:4411580-4411990 [Klebsiella pneumoniae subsp. pneumoniae PittNDM01]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGAAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT45619 WP_002916312.1 NZ_CP006798:4411333-4411599 [Klebsiella pneumoniae subsp. pneumoniae PittNDM01]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT45619 NZ_CP006798:4411333-4411599 [Klebsiella pneumoniae subsp. pneumoniae PittNDM01]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41