Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4375117..4375737 Replicon chromosome
Accession NZ_CP006792
Organism Yersinia pestis 2944

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag M478_RS21270 Protein ID WP_002208622.1
Coordinates 4375117..4375320 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag M478_RS21275 Protein ID WP_002218472.1
Coordinates 4375369..4375737 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M478_RS21245 4370139..4370477 + 339 WP_002208627.1 P-II family nitrogen regulator -
M478_RS21250 4370517..4371806 + 1290 WP_002228344.1 ammonium transporter AmtB -
M478_RS21255 4372066..4372926 - 861 WP_002208625.1 acyl-CoA thioesterase II -
M478_RS21260 4373183..4373704 + 522 WP_002208624.1 lipoprotein -
M478_RS21265 4373840..4374229 - 390 WP_002208623.1 MGMT family protein -
M478_RS21270 4375117..4375320 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
M478_RS21275 4375369..4375737 - 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
M478_RS21280 4375896..4376249 - 354 WP_002208619.1 hypothetical protein -
M478_RS21285 4377123..4377266 - 144 WP_002208618.1 type B 50S ribosomal protein L36 -
M478_RS21290 4377282..4377542 - 261 WP_002208617.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T45602 WP_002208622.1 NZ_CP006792:c4375320-4375117 [Yersinia pestis 2944]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T45602 NZ_CP006792:c4375320-4375117 [Yersinia pestis 2944]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT45602 WP_002218472.1 NZ_CP006792:c4375737-4375369 [Yersinia pestis 2944]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT45602 NZ_CP006792:c4375737-4375369 [Yersinia pestis 2944]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References