Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 1354980..1355626 Replicon chromosome
Accession NZ_CP006792
Organism Yersinia pestis 2944

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag M478_RS07535 Protein ID WP_002214976.1
Coordinates 1354980..1355162 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag M478_RS07540 Protein ID WP_002211129.1
Coordinates 1355207..1355626 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M478_RS07500 1350366..1350836 + 471 WP_002227961.1 flagellar basal body-associated protein FliL -
M478_RS07505 1350842..1351843 + 1002 WP_002211135.1 flagellar motor switch protein FliM -
M478_RS07510 1351840..1352256 + 417 WP_002211134.1 flagellar motor switch protein FliN -
M478_RS07515 1352256..1352792 + 537 WP_002211133.1 flagellar biosynthetic protein FliO -
M478_RS07520 1352873..1353613 + 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
M478_RS07525 1353719..1353988 + 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
M478_RS07530 1353991..1354773 + 783 WP_002211130.1 flagellar type III secretion system protein FliR -
M478_RS07535 1354980..1355162 + 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
M478_RS07540 1355207..1355626 + 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M478_RS07545 1355884..1356843 - 960 WP_002223882.1 sugar kinase -
M478_RS07550 1356892..1357914 - 1023 WP_002214974.1 ABC transporter permease -
M478_RS07555 1357917..1359494 - 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
M478_RS07560 1359560..1360555 - 996 WP_002211125.1 substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T45591 WP_002214976.1 NZ_CP006792:1354980-1355162 [Yersinia pestis 2944]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T45591 NZ_CP006792:1354980-1355162 [Yersinia pestis 2944]
GTGAAAAGTTCGGAGCTGATAAAACTGCTCGAAACAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCCAAAAAGGATGTTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT45591 WP_002211129.1 NZ_CP006792:1355207-1355626 [Yersinia pestis 2944]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT45591 NZ_CP006792:1355207-1355626 [Yersinia pestis 2944]
ATGGCTATCTATCCCGCCTATGTTCACGTTGATAATGATGGCTCGGCAAGCGGTTATTTCCCCGATGTCAAAGGCTGTAT
TTTTGCCATCAATGCCGGGGAGGATTTATTTGCAGAAGCATCAAGCGCCCTGGATGCACACTTTGAAGCTTTGGTGTCTG
AAGGTATCGAAATTCCTGAAGCTCATGACATGCCTTACCACGTTTACCGTAACCCATGCGATTACGCTGATGGCGGACAG
TGGTATAACGTGAATATTGATATGTCGAAATATGATGGAAAAGTTGAACGAATTAACGTCACTCTTCCGCACCGGCTGAT
TCATCAAATCGATACTATTGTTAAAGTGCGTCCCGAGTATGCCAGCCGAAGCAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References