Detailed information of TA system TA045590

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 891052..892018
• Replicon: chromosome
• Accession: NZ_CP006792
• Organism: Yersinia pestis 2944

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E8XJV6
• Locus tag: M478_RS05220
• Protein ID: WP_002210981.1
• Coordinates: 891052..891510 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q66A69
• Locus tag: M478_RS05225
• Protein ID: WP_002210982.1
• Coordinates: 891572..892018 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M478_RS05190	886866..887531	+	666	WP_002210975.1	phage shock protein PspA	-
M478_RS05195	887693..887920	+	228	WP_002210976.1	envelope stress response membrane protein PspB	-
M478_RS05200	887920..888279	+	360	WP_002210977.1	envelope stress response membrane protein PspC	-
M478_RS05205	888364..888606	+	243	WP_002216375.1	phage shock protein PspD	-
M478_RS05210	888587..889984	+	1398	WP_002210979.1	YcjX family protein	-
M478_RS05215	889981..891042	+	1062	WP_002210980.1	YcjF family protein	-
M478_RS05220	891052..891510	-	459	WP_002210981.1	RES family NAD+ phosphorylase	Toxin
M478_RS05225	891572..892018	-	447	WP_002210982.1	DUF2384 domain-containing protein	Antitoxin
M478_RS05230	892354..893931	+	1578	WP_002210983.1	transcriptional regulator TyrR	-
M478_RS05235	894078..894485	-	408	WP_050881432.1	IS200/IS605 family transposase	-
M478_RS05240	894790..895293	-	504	WP_002210984.1	thiol peroxidase	-
M478_RS05245	895456..896430	+	975	WP_002210985.1	L-Ala-D/L-Glu epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	894078..894323	245

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 16994.38 Da
• Isoelectric Point: 4.8732

>T45590 WP_002210981.1 NZ_CP006792:c891510-891052 [Yersinia pestis 2944]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T45590 NZ_CP006792:c891510-891052 [Yersinia pestis 2944]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16401.94 Da
• Isoelectric Point: 9.7155

>AT45590 WP_002210982.1 NZ_CP006792:c892018-891572 [Yersinia pestis 2944]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT45590 NZ_CP006792:c892018-891572 [Yersinia pestis 2944]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: A0A0E8XJV6

Antitoxin

• AlphaFold DB: A0A0E8XFL1