Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4424911..4425531 Replicon chromosome
Accession NZ_CP006783
Organism Yersinia pestis 1412

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag M479_RS21525 Protein ID WP_002208622.1
Coordinates 4424911..4425114 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag M479_RS21530 Protein ID WP_002218472.1
Coordinates 4425163..4425531 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M479_RS21500 4419933..4420271 + 339 WP_002208627.1 P-II family nitrogen regulator -
M479_RS21505 4420311..4421600 + 1290 WP_002228344.1 ammonium transporter AmtB -
M479_RS21510 4421860..4422720 - 861 WP_002208625.1 acyl-CoA thioesterase II -
M479_RS21515 4422977..4423498 + 522 WP_011906379.1 YbaY family lipoprotein -
M479_RS21520 4423634..4424023 - 390 WP_002208623.1 MGMT family protein -
M479_RS21525 4424911..4425114 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
M479_RS21530 4425163..4425531 - 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
M479_RS21535 4425690..4426043 - 354 WP_002208619.1 hypothetical protein -
M479_RS21540 4426917..4427060 - 144 WP_002208618.1 type B 50S ribosomal protein L36 -
M479_RS21545 4427076..4427336 - 261 WP_002208617.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T45588 WP_002208622.1 NZ_CP006783:c4425114-4424911 [Yersinia pestis 1412]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T45588 NZ_CP006783:c4425114-4424911 [Yersinia pestis 1412]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT45588 WP_002218472.1 NZ_CP006783:c4425531-4425163 [Yersinia pestis 1412]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT45588 NZ_CP006783:c4425531-4425163 [Yersinia pestis 1412]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCAGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References