Detailed information of TA system TA045576

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 1211268..1212268
• Replicon: chromosome
• Accession: NZ_CP006783
• Organism: Yersinia pestis 1412

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E8XJV6
• Locus tag: M479_RS06700
• Protein ID: WP_002210981.1
• Coordinates: 1211268..1211726 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q66A69
• Locus tag: M479_RS06705
• Protein ID: WP_002210982.1
• Coordinates: 1211822..1212268 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M479_RS06670	1207082..1207747	+	666	WP_002210975.1	phage shock protein PspA	-
M479_RS06675	1207909..1208136	+	228	WP_002210976.1	envelope stress response membrane protein PspB	-
M479_RS06680	1208136..1208495	+	360	WP_002210977.1	envelope stress response membrane protein PspC	-
M479_RS06685	1208580..1208822	+	243	WP_002216375.1	phage shock protein PspD	-
M479_RS06690	1208803..1210200	+	1398	WP_011906190.1	YcjX family protein	-
M479_RS06695	1210197..1211258	+	1062	WP_002210980.1	YcjF family protein	-
M479_RS06700	1211268..1211726	-	459	WP_002210981.1	RES family NAD+ phosphorylase	Toxin
M479_RS06705	1211822..1212268	-	447	WP_002210982.1	DUF2384 domain-containing protein	Antitoxin
M479_RS06710	1212604..1214181	+	1578	WP_002210983.1	transcriptional regulator TyrR	-
M479_RS06715	1214328..1214786	-	459	WP_002213759.1	IS200/IS605-like element IS1541A family transposase	-
M479_RS23970	1214935..1215715	-	781	Protein_1052	IS21-like element IS100kyp family helper ATPase IstB	-
M479_RS06730	1215712..1216733	-	1022	Protein_1053	IS21-like element IS100 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 16994.38 Da
• Isoelectric Point: 4.8732

>T45576 WP_002210981.1 NZ_CP006783:c1211726-1211268 [Yersinia pestis 1412]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T45576 NZ_CP006783:c1211726-1211268 [Yersinia pestis 1412]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16401.94 Da
• Isoelectric Point: 9.7155

>AT45576 WP_002210982.1 NZ_CP006783:c1212268-1211822 [Yersinia pestis 1412]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT45576 NZ_CP006783:c1212268-1211822 [Yersinia pestis 1412]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: A0A0E8XJV6

Antitoxin

• AlphaFold DB: A0A0E8XFL1