Detailed information of TA system TA045574

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-couple_hipB
• Location: 371486..372732
• Replicon: chromosome
• Accession: NZ_CP006770
• Organism: Streptococcus equi subsp. zooepidemicus CY

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: A0A6D2LV21
• Locus tag: Q426_RS01780
• Protein ID: WP_014623239.1
• Coordinates: 371962..372732 (+)
• Length: 257 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: Q426_RS01775
• Protein ID: WP_014623240.1
• Coordinates: 371486..371962 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Q426_RS01745	366943..368457	+	1515	WP_038674112.1	ABC transporter ATP-binding protein/permease	-
Q426_RS01750	368640..369278	+	639	WP_014623243.1	hypothetical protein	-
Q426_RS01755	369317..370403	+	1087	Protein_339	toprim domain-containing protein	-
Q426_RS01760	370457..370684	+	228	WP_000110926.1	hypothetical protein	-
Q426_RS01765	370688..371083	+	396	WP_014623241.1	hypothetical protein	-
Q426_RS01770	371128..371415	+	288	WP_038674119.1	hypothetical protein	-
Q426_RS01775	371486..371962	+	477	WP_014623240.1	helix-turn-helix domain-containing protein	Antitoxin
Q426_RS01780	371962..372732	+	771	WP_014623239.1	zeta toxin family protein	Toxin
Q426_RS01785	372735..374006	+	1272	WP_038674121.1	hypothetical protein	-
Q426_RS01790	373999..374685	+	687	WP_014623237.1	hypothetical protein	-
Q426_RS01795	374690..377335	+	2646	WP_014623236.1	AAA family ATPase	-
Q426_RS09975	377465..377656	+	192	WP_014623235.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	368640..383598	14958

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (26-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 257 a.a.
• Molecular weight: 29112.91 Da
• Isoelectric Point: 5.8794

>T45574 WP_014623239.1 NZ_CP006770:371962-372732 [Streptococcus equi subsp. zooepidemicus CY]
MRLEEFSQDDFDLALKRTIRSLTRGKTTSVSPKAILLGGQSGAGKTTIHRIEQKEFQGNIIIIDGDSYRSLHPNYLALHE
EYGKDSVDYTKGFAGKMVEHLVDELSKQGYHLLIEGTLRTTEVPRKTARLLNSRGYQVSLALIATKPELSYLSTLIRYEE
VYAVNPNQARATPKEHHDGIVDHLVDNLRELENDKLFGQIQIYQRDRTCVYDSKTDEGSAADVLQECLFGKWSKVEEEML
KVGQECLRELEFKGEC

Nucleotide

• Length: 771 bp

>T45574 NZ_CP006770:371962-372732 [Streptococcus equi subsp. zooepidemicus CY]
ATGCGGTTAGAAGAATTTAGTCAAGATGACTTTGACCTAGCCTTAAAACGAACCATTCGTTCTTTAACTCGTGGTAAAAC
AACATCAGTTAGTCCAAAGGCAATTTTACTTGGTGGACAAAGCGGAGCAGGAAAAACAACGATACACCGTATCGAGCAAA
AAGAGTTTCAAGGGAATATCATTATTATTGACGGCGATAGCTATCGTTCTTTACACCCGAATTATCTAGCTTTACACGAA
GAATACGGTAAGGATAGCGTGGATTATACCAAAGGTTTTGCAGGAAAAATGGTGGAACATCTTGTCGATGAGCTAAGTAA
ACAAGGTTATCATTTGTTAATTGAAGGAACCTTGAGAACGACAGAAGTCCCACGAAAAACAGCTCGGTTATTGAATTCGA
GAGGTTATCAAGTCTCTTTAGCTTTGATAGCGACCAAGCCTGAATTGTCATATCTCAGTACCTTAATACGCTATGAGGAA
GTCTATGCGGTGAACCCAAACCAGGCTAGAGCAACTCCTAAAGAACATCACGATGGTATTGTAGACCATTTAGTCGATAA
TCTAAGAGAGTTAGAAAACGATAAACTCTTTGGCCAGATTCAAATATATCAAAGAGATAGAACCTGTGTCTATGATTCAA
AGACGGATGAAGGTTCAGCAGCCGATGTCCTACAAGAATGCCTCTTCGGAAAATGGAGTAAGGTCGAGGAAGAGATGTTG
AAGGTGGGACAAGAATGTTTGAGGGAGTTAGAGTTTAAAGGAGAGTGCTGA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18032.39 Da
• Isoelectric Point: 4.3193

>AT45574 WP_014623240.1 NZ_CP006770:371486-371962 [Streptococcus equi subsp. zooepidemicus CY]
MIGDNIKSLRKTHDLTQPEFAKIVGISRNSLSRYENGTSSVSTELIDRICQKFNVSYVDIVGEEKLLTPVEDYQLTLKVE
VIKERGAAILSELYCYQDSQGIAFDDETSPWILMSDDLSDLINTKIYLVNTFDEVERYNGYLDGIERMLELARHQVVA

Nucleotide

• Length: 477 bp

>AT45574 NZ_CP006770:371486-371962 [Streptococcus equi subsp. zooepidemicus CY]
ATGATTGGAGACAATATCAAATCGTTACGTAAAACCCATGATTTAACACAACCAGAATTCGCAAAGATTGTGGGAATTTC
ACGAAATAGCCTTAGTCGTTATGAAAATGGAACCAGCTCTGTTTCAACAGAACTGATAGATCGTATTTGTCAGAAATTCA
ACGTGTCTTATGTCGACATTGTAGGAGAAGAAAAGCTGTTAACACCAGTAGAAGATTATCAATTGACGCTGAAAGTCGAA
GTCATCAAAGAACGTGGTGCAGCGATTTTATCCGAACTGTATTGCTATCAAGATAGTCAAGGAATTGCTTTTGATGATGA
GACTAGCCCTTGGATTTTGATGAGTGATGACTTGTCAGACCTTATCAACACTAAGATTTACCTTGTCAATACCTTTGACG
AAGTAGAGCGCTACAATGGTTATTTGGATGGCATTGAGCGTATGTTGGAGCTTGCTCGACATCAGGTGGTGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A6D2LV21