Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 4011396..4012042 Replicon chromosome
Accession NZ_CP006762
Organism Yersinia pestis 1413

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag M480_RS19560 Protein ID WP_002214976.1
Coordinates 4011860..4012042 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag M480_RS19555 Protein ID WP_002211129.1
Coordinates 4011396..4011815 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M480_RS19535 4006467..4007462 + 996 WP_002211125.1 substrate-binding domain-containing protein -
M480_RS19540 4007528..4009105 + 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
M480_RS19545 4009108..4010130 + 1023 WP_002214974.1 ABC transporter permease -
M480_RS19550 4010179..4011138 + 960 WP_002211128.1 sugar kinase -
M480_RS19555 4011396..4011815 - 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M480_RS19560 4011860..4012042 - 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
M480_RS19565 4012249..4013031 - 783 WP_002211130.1 flagellar type III secretion system protein FliR -
M480_RS19570 4013034..4013303 - 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
M480_RS19575 4013409..4014149 - 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
M480_RS19580 4014230..4014766 - 537 WP_002211133.1 flagellar biosynthetic protein FliO -
M480_RS19585 4014766..4015182 - 417 WP_011906247.1 flagellar motor switch protein FliN -
M480_RS19590 4015179..4016180 - 1002 WP_002211135.1 flagellar motor switch protein FliM -
M480_RS19595 4016186..4016656 - 471 WP_002227961.1 flagellar basal body-associated protein FliL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T45571 WP_002214976.1 NZ_CP006762:c4012042-4011860 [Yersinia pestis 1413]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T45571 NZ_CP006762:c4012042-4011860 [Yersinia pestis 1413]
GTGAAAAGTTCGGAGCTGATAAAACTGCTCGAAACAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCCAAAAAGGATGTTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT45571 WP_002211129.1 NZ_CP006762:c4011815-4011396 [Yersinia pestis 1413]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT45571 NZ_CP006762:c4011815-4011396 [Yersinia pestis 1413]
ATGGCTATCTATCCCGCCTATGTTCACGTTGATAATGATGGCTCGGCAAGCGGTTATTTCCCCGATGTCAAAGGCTGTAT
TTTTGCCATCAATGCCGGGGAGGATTTATTTGCAGAAGCATCAAGCGCCCTGGATGCACACTTTGAAGCTTTGGTGTCTG
AAGGTATCGAAATTCCTGAAGCTCATGACATGCCTTACCACGTTTACCGTAACCCATGCGATTACGCTGATGGCGGACAG
TGGTATAACGTGAATATTGATATGTCGAAATATGATGGAAAAGTTGAACGAATTAACGTCACTCTTCCGCACCGGCTGAT
TCATCAAATCGATACTATTGTTAAAGTGCGTCCCGAGTATGCCAGCCGAAGCAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References