Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3446660..3447332 Replicon chromosome
Accession NZ_CP006762
Organism Yersinia pestis 1413

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag M480_RS16850 Protein ID WP_002215144.1
Coordinates 3446907..3447332 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag M480_RS16845 Protein ID WP_002209939.1
Coordinates 3446660..3446926 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M480_RS16825 3442517..3443620 + 1104 WP_002209943.1 hypothetical protein -
M480_RS16830 3443822..3444523 + 702 WP_002209942.1 hemolysin III family protein -
M480_RS16835 3444781..3445278 + 498 WP_002209941.1 DUF2165 family protein -
M480_RS16840 3445351..3446343 - 993 WP_002209940.1 tRNA-modifying protein YgfZ -
M480_RS16845 3446660..3446926 + 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
M480_RS16850 3446907..3447332 + 426 WP_002215144.1 protein YgfX Toxin
M480_RS16855 3447332..3448030 + 699 WP_002209937.1 two-component system response regulator CreB -
M480_RS16860 3448055..3449473 + 1419 WP_002209936.1 two-component system sensor histidine kinase CreC -
M480_RS16865 3449594..3451051 + 1458 WP_002220113.1 cell envelope integrity protein CreD -
M480_RS16870 3451141..3451659 - 519 WP_002209934.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T45561 WP_002215144.1 NZ_CP006762:3446907-3447332 [Yersinia pestis 1413]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T45561 NZ_CP006762:3446907-3447332 [Yersinia pestis 1413]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCACACGGCATATTGGTCAT
TTTAACCTTGGTCGCGCCCTGGCCCTTGGGTTATACCGCCCTATGGCTGGTATTGCTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCGATGGAAAAGGCAT
GAATGGACCGTGGTCAAGCCGCCGTGGATCACCCGCTATGGGGTATTATTACATTTACAACAAACAGGCGGCCACGCGAC
CCGAAAGCGTCTATGGCTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTGCTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT45561 WP_002209939.1 NZ_CP006762:3446660-3446926 [Yersinia pestis 1413]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT45561 NZ_CP006762:3446660-3446926 [Yersinia pestis 1413]
ATGGAAATTGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGCTTGCTTGAGTGTGATGACCCAGATT
TATTCAACTGGCTGATGAACCACGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTCAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References