Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1363427..1364047 Replicon chromosome
Accession NZ_CP006762
Organism Yersinia pestis 1413

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag M480_RS07430 Protein ID WP_002208622.1
Coordinates 1363844..1364047 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag M480_RS07425 Protein ID WP_002218472.1
Coordinates 1363427..1363795 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M480_RS07410 1361622..1361882 + 261 WP_002208617.1 type B 50S ribosomal protein L31 -
M480_RS07415 1361898..1362041 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
M480_RS07420 1362915..1363268 + 354 WP_002208619.1 hypothetical protein -
M480_RS07425 1363427..1363795 + 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
M480_RS07430 1363844..1364047 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
M480_RS07435 1364935..1365324 + 390 WP_002208623.1 MGMT family protein -
M480_RS07440 1365460..1365981 - 522 WP_011906379.1 YbaY family lipoprotein -
M480_RS07445 1366238..1367098 + 861 WP_002208625.1 acyl-CoA thioesterase II -
M480_RS07450 1367358..1368647 - 1290 WP_002228344.1 ammonium transporter AmtB -
M480_RS07455 1368687..1369025 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T45560 WP_002208622.1 NZ_CP006762:1363844-1364047 [Yersinia pestis 1413]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T45560 NZ_CP006762:1363844-1364047 [Yersinia pestis 1413]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT45560 WP_002218472.1 NZ_CP006762:1363427-1363795 [Yersinia pestis 1413]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT45560 NZ_CP006762:1363427-1363795 [Yersinia pestis 1413]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCAGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References