Detailed information of TA system TA045559

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 51891..52891
• Replicon: chromosome
• Accession: NZ_CP006762
• Organism: Yersinia pestis 1413

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E8XJV6
• Locus tag: M480_RS01440
• Protein ID: WP_002210981.1
• Coordinates: 52433..52891 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q66A69
• Locus tag: M480_RS01435
• Protein ID: WP_002210982.1
• Coordinates: 51891..52337 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M480_RS01415	47423..48445	+	1023	WP_050880968.1	IS21-like element IS100 family transposase	-
M480_RS01420	48445..49224	+	780	WP_001297096.1	IS21-like element IS100kyp family helper ATPase IstB	-
M480_RS01425	49373..49831	+	459	WP_002213759.1	IS200/IS605-like element IS1541A family transposase	-
M480_RS01430	49978..51555	-	1578	WP_002210983.1	transcriptional regulator TyrR	-
M480_RS01435	51891..52337	+	447	WP_002210982.1	DUF2384 domain-containing protein	Antitoxin
M480_RS01440	52433..52891	+	459	WP_002210981.1	RES family NAD+ phosphorylase	Toxin
M480_RS01445	52901..53962	-	1062	WP_002210980.1	YcjF family protein	-
M480_RS01450	53959..55356	-	1398	WP_011906190.1	YcjX family protein	-
M480_RS01455	55337..55579	-	243	WP_002216375.1	phage shock protein PspD	-
M480_RS01460	55664..56023	-	360	WP_002210977.1	envelope stress response membrane protein PspC	-
M480_RS01465	56023..56250	-	228	WP_002210976.1	envelope stress response membrane protein PspB	-
M480_RS01470	56412..57077	-	666	WP_002210975.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 16994.38 Da
• Isoelectric Point: 4.8732

>T45559 WP_002210981.1 NZ_CP006762:52433-52891 [Yersinia pestis 1413]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T45559 NZ_CP006762:52433-52891 [Yersinia pestis 1413]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16401.94 Da
• Isoelectric Point: 9.7155

>AT45559 WP_002210982.1 NZ_CP006762:51891-52337 [Yersinia pestis 1413]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT45559 NZ_CP006762:51891-52337 [Yersinia pestis 1413]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: A0A0E8XJV6

Antitoxin

• AlphaFold DB: A0A0E8XFL1