Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3800914..3801586 Replicon chromosome
Accession NZ_CP006758
Organism Yersinia pestis 1522

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag M481_RS18805 Protein ID WP_002215144.1
Coordinates 3800914..3801339 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag M481_RS18810 Protein ID WP_002209939.1
Coordinates 3801320..3801586 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M481_RS18785 3796587..3797105 + 519 WP_002209934.1 flavodoxin FldB -
M481_RS18790 3797195..3798652 - 1458 WP_002220113.1 cell envelope integrity protein CreD -
M481_RS18795 3798773..3800191 - 1419 WP_002209936.1 two-component system sensor histidine kinase CreC -
M481_RS18800 3800216..3800914 - 699 WP_002209937.1 two-component system response regulator CreB -
M481_RS18805 3800914..3801339 - 426 WP_002215144.1 protein YgfX Toxin
M481_RS18810 3801320..3801586 - 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
M481_RS18815 3801903..3802895 + 993 WP_002209940.1 tRNA-modifying protein YgfZ -
M481_RS18820 3802968..3803465 - 498 WP_002209941.1 DUF2165 family protein -
M481_RS18825 3803723..3804424 - 702 WP_002209942.1 hemolysin III family protein -
M481_RS18830 3804626..3805729 - 1104 WP_002209943.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T45557 WP_002215144.1 NZ_CP006758:c3801339-3800914 [Yersinia pestis 1522]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T45557 NZ_CP006758:c3801339-3800914 [Yersinia pestis 1522]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCACACGGCATATTGGTCAT
TTTAACCTTGGTCGCGCCCTGGCCCTTGGGTTATACCGCCCTATGGCTGGTATTGCTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCGATGGAAAAGGCAT
GAATGGACCGTGGTCAAGCCGCCGTGGATCACCCGCTATGGGGTATTATTACATTTACAACAAACAGGCGGCCACGCGAC
CCGAAAGCGTCTATGGCTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTGCTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT45557 WP_002209939.1 NZ_CP006758:c3801586-3801320 [Yersinia pestis 1522]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT45557 NZ_CP006758:c3801586-3801320 [Yersinia pestis 1522]
ATGGAAATTGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGCTTGCTTGAGTGTGATGACCCAGATT
TATTCAACTGGCTGATGAACCACGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTCAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References