Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 3236093..3236739 Replicon chromosome
Accession NZ_CP006758
Organism Yersinia pestis 1522

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag M481_RS16105 Protein ID WP_002214976.1
Coordinates 3236093..3236275 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag M481_RS16110 Protein ID WP_002211129.1
Coordinates 3236320..3236739 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M481_RS16070 3231479..3231949 + 471 WP_002227961.1 flagellar basal body-associated protein FliL -
M481_RS16075 3231955..3232956 + 1002 WP_002211135.1 flagellar motor switch protein FliM -
M481_RS16080 3232953..3233369 + 417 WP_011906247.1 flagellar motor switch protein FliN -
M481_RS16085 3233369..3233905 + 537 WP_002211133.1 flagellar biosynthetic protein FliO -
M481_RS16090 3233986..3234726 + 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
M481_RS16095 3234832..3235101 + 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
M481_RS16100 3235104..3235886 + 783 WP_002211130.1 flagellar type III secretion system protein FliR -
M481_RS16105 3236093..3236275 + 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
M481_RS16110 3236320..3236739 + 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M481_RS16115 3236997..3237956 - 960 WP_002211128.1 sugar kinase -
M481_RS16120 3238005..3239027 - 1023 WP_002214974.1 ABC transporter permease -
M481_RS16125 3239030..3240607 - 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
M481_RS16130 3240673..3241668 - 996 WP_002211125.1 substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T45547 WP_002214976.1 NZ_CP006758:3236093-3236275 [Yersinia pestis 1522]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T45547 NZ_CP006758:3236093-3236275 [Yersinia pestis 1522]
GTGAAAAGTTCGGAGCTGATAAAACTGCTCGAAACAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCCAAAAAGGATGTTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT45547 WP_002211129.1 NZ_CP006758:3236320-3236739 [Yersinia pestis 1522]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT45547 NZ_CP006758:3236320-3236739 [Yersinia pestis 1522]
ATGGCTATCTATCCCGCCTATGTTCACGTTGATAATGATGGCTCGGCAAGCGGTTATTTCCCCGATGTCAAAGGCTGTAT
TTTTGCCATCAATGCCGGGGAGGATTTATTTGCAGAAGCATCAAGCGCCCTGGATGCACACTTTGAAGCTTTGGTGTCTG
AAGGTATCGAAATTCCTGAAGCTCATGACATGCCTTACCACGTTTACCGTAACCCATGCGATTACGCTGATGGCGGACAG
TGGTATAACGTGAATATTGATATGTCGAAATATGATGGAAAAGTTGAACGAATTAACGTCACTCTTCCGCACCGGCTGAT
TCATCAAATCGATACTATTGTTAAAGTGCGTCCCGAGTATGCCAGCCGAAGCAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References