Detailed information of TA system TA045546

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 2666997..2667963
• Replicon: chromosome
• Accession: NZ_CP006758
• Organism: Yersinia pestis 1522

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E8XJV6
• Locus tag: M481_RS13420
• Protein ID: WP_002210981.1
• Coordinates: 2666997..2667455 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q66A69
• Locus tag: M481_RS13425
• Protein ID: WP_002210982.1
• Coordinates: 2667517..2667963 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M481_RS13390	2662811..2663476	+	666	WP_002210975.1	phage shock protein PspA	-
M481_RS13395	2663638..2663865	+	228	WP_002210976.1	envelope stress response membrane protein PspB	-
M481_RS13400	2663865..2664224	+	360	WP_002210977.1	envelope stress response membrane protein PspC	-
M481_RS13405	2664309..2664551	+	243	WP_002216375.1	phage shock protein PspD	-
M481_RS13410	2664532..2665929	+	1398	WP_011906190.1	YcjX family protein	-
M481_RS13415	2665926..2666987	+	1062	WP_002210980.1	YcjF family protein	-
M481_RS13420	2666997..2667455	-	459	WP_002210981.1	RES family NAD+ phosphorylase	Toxin
M481_RS13425	2667517..2667963	-	447	WP_002210982.1	DUF2384 domain-containing protein	Antitoxin
M481_RS13430	2668299..2669876	+	1578	WP_002210983.1	transcriptional regulator TyrR	-
M481_RS13435	2670023..2670481	-	459	WP_002213759.1	IS200/IS605-like element IS1541A family transposase	-
M481_RS13440	2670630..2671409	-	780	WP_001297096.1	IS21-like element IS100kyp family helper ATPase IstB	-
M481_RS13445	2671409..2672431	-	1023	WP_011901829.1	IS21-like element IS100 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 16994.38 Da
• Isoelectric Point: 4.8732

>T45546 WP_002210981.1 NZ_CP006758:c2667455-2666997 [Yersinia pestis 1522]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T45546 NZ_CP006758:c2667455-2666997 [Yersinia pestis 1522]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16401.94 Da
• Isoelectric Point: 9.7155

>AT45546 WP_002210982.1 NZ_CP006758:c2667963-2667517 [Yersinia pestis 1522]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT45546 NZ_CP006758:c2667963-2667517 [Yersinia pestis 1522]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: A0A0E8XJV6

Antitoxin

• AlphaFold DB: A0A0E8XFL1