Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1355091..1355711 Replicon chromosome
Accession NZ_CP006758
Organism Yersinia pestis 1522

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag M481_RS07400 Protein ID WP_002208622.1
Coordinates 1355091..1355294 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag M481_RS07405 Protein ID WP_002218472.1
Coordinates 1355343..1355711 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M481_RS07375 1350113..1350451 + 339 WP_002208627.1 P-II family nitrogen regulator -
M481_RS07380 1350491..1351780 + 1290 WP_002228344.1 ammonium transporter AmtB -
M481_RS07385 1352040..1352900 - 861 WP_002208625.1 acyl-CoA thioesterase II -
M481_RS07390 1353157..1353678 + 522 WP_011906379.1 YbaY family lipoprotein -
M481_RS07395 1353814..1354203 - 390 WP_002208623.1 MGMT family protein -
M481_RS07400 1355091..1355294 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
M481_RS07405 1355343..1355711 - 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
M481_RS07410 1355870..1356223 - 354 WP_002208619.1 hypothetical protein -
M481_RS07415 1357097..1357240 - 144 WP_002208618.1 type B 50S ribosomal protein L36 -
M481_RS07420 1357256..1357516 - 261 WP_002208617.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T45545 WP_002208622.1 NZ_CP006758:c1355294-1355091 [Yersinia pestis 1522]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T45545 NZ_CP006758:c1355294-1355091 [Yersinia pestis 1522]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT45545 WP_002218472.1 NZ_CP006758:c1355711-1355343 [Yersinia pestis 1522]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT45545 NZ_CP006758:c1355711-1355343 [Yersinia pestis 1522]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCAGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References