Detailed information of TA system TA045544

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 3741209..3742209
• Replicon: chromosome
• Accession: NZ_CP006754
• Organism: Yersinia pestis 3067

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E8XJV6
• Locus tag: M482_RS18530
• Protein ID: WP_002210981.1
• Coordinates: 3741751..3742209 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q66A69
• Locus tag: M482_RS18525
• Protein ID: WP_002210982.1
• Coordinates: 3741209..3741655 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M482_RS18505	3736741..3737763	+	1023	WP_011901829.1	IS21-like element IS100 family transposase	-
M482_RS18510	3737763..3738542	+	780	WP_001297096.1	IS21-like element IS100kyp family helper ATPase IstB	-
M482_RS18515	3738691..3739149	+	459	WP_002213759.1	IS200/IS605-like element IS1541A family transposase	-
M482_RS18520	3739296..3740873	-	1578	WP_002210983.1	transcriptional regulator TyrR	-
M482_RS18525	3741209..3741655	+	447	WP_002210982.1	DUF2384 domain-containing protein	Antitoxin
M482_RS18530	3741751..3742209	+	459	WP_002210981.1	RES family NAD+ phosphorylase	Toxin
M482_RS18535	3742219..3743280	-	1062	WP_002210980.1	YcjF family protein	-
M482_RS18540	3743277..3744674	-	1398	WP_011906190.1	YcjX family protein	-
M482_RS18545	3744655..3744897	-	243	WP_002216375.1	phage shock protein PspD	-
M482_RS18550	3744982..3745341	-	360	WP_002210977.1	envelope stress response membrane protein PspC	-
M482_RS18555	3745341..3745568	-	228	WP_002210976.1	envelope stress response membrane protein PspB	-
M482_RS18560	3745730..3746395	-	666	WP_002210975.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 16994.38 Da
• Isoelectric Point: 4.8732

>T45544 WP_002210981.1 NZ_CP006754:3741751-3742209 [Yersinia pestis 3067]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T45544 NZ_CP006754:3741751-3742209 [Yersinia pestis 3067]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16401.94 Da
• Isoelectric Point: 9.7155

>AT45544 WP_002210982.1 NZ_CP006754:3741209-3741655 [Yersinia pestis 3067]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT45544 NZ_CP006754:3741209-3741655 [Yersinia pestis 3067]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: A0A0E8XJV6

Antitoxin

• AlphaFold DB: A0A0E8XFL1