Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 3170202..3170848 Replicon chromosome
Accession NZ_CP006754
Organism Yersinia pestis 3067

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag M482_RS15830 Protein ID WP_002214976.1
Coordinates 3170666..3170848 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag M482_RS15825 Protein ID WP_002211129.1
Coordinates 3170202..3170621 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M482_RS15805 3165273..3166268 + 996 WP_002211125.1 substrate-binding domain-containing protein -
M482_RS15810 3166334..3167911 + 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
M482_RS15815 3167914..3168936 + 1023 WP_002214974.1 ABC transporter permease -
M482_RS15820 3168985..3169944 + 960 WP_002211128.1 sugar kinase -
M482_RS15825 3170202..3170621 - 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M482_RS15830 3170666..3170848 - 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
M482_RS15835 3171055..3171837 - 783 WP_002211130.1 flagellar type III secretion system protein FliR -
M482_RS15840 3171840..3172109 - 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
M482_RS15845 3172215..3172955 - 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
M482_RS15850 3173036..3173572 - 537 WP_002211133.1 flagellar biosynthetic protein FliO -
M482_RS15855 3173572..3173988 - 417 WP_011906247.1 flagellar motor switch protein FliN -
M482_RS15860 3173985..3174986 - 1002 WP_002211135.1 flagellar motor switch protein FliM -
M482_RS15865 3174992..3175462 - 471 WP_002227961.1 flagellar basal body-associated protein FliL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T45543 WP_002214976.1 NZ_CP006754:c3170848-3170666 [Yersinia pestis 3067]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T45543 NZ_CP006754:c3170848-3170666 [Yersinia pestis 3067]
GTGAAAAGTTCGGAGCTGATAAAACTGCTCGAAACAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCCAAAAAGGATGTTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT45543 WP_002211129.1 NZ_CP006754:c3170621-3170202 [Yersinia pestis 3067]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT45543 NZ_CP006754:c3170621-3170202 [Yersinia pestis 3067]
ATGGCTATCTATCCCGCCTATGTTCACGTTGATAATGATGGCTCGGCAAGCGGTTATTTCCCCGATGTCAAAGGCTGTAT
TTTTGCCATCAATGCCGGGGAGGATTTATTTGCAGAAGCATCAAGCGCCCTGGATGCACACTTTGAAGCTTTGGTGTCTG
AAGGTATCGAAATTCCTGAAGCTCATGACATGCCTTACCACGTTTACCGTAACCCATGCGATTACGCTGATGGCGGACAG
TGGTATAACGTGAATATTGATATGTCGAAATATGATGGAAAAGTTGAACGAATTAACGTCACTCTTCCGCACCGGCTGAT
TCATCAAATCGATACTATTGTTAAAGTGCGTCCCGAGTATGCCAGCCGAAGCAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References