Detailed information of TA system TA045530

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 3878302..3879302
• Replicon: chromosome
• Accession: NZ_CP006751
• Organism: Yersinia pestis 3770

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E8XJV6
• Locus tag: M483_RS19075
• Protein ID: WP_002210981.1
• Coordinates: 3878844..3879302 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q66A69
• Locus tag: M483_RS19070
• Protein ID: WP_002210982.1
• Coordinates: 3878302..3878748 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M483_RS19050	3873834..3874856	+	1023	WP_050882116.1	IS21-like element IS100 family transposase	-
M483_RS19055	3874856..3875635	+	780	WP_001297096.1	IS21-like element IS100kyp family helper ATPase IstB	-
M483_RS19060	3875784..3876242	+	459	WP_002213759.1	IS200/IS605-like element IS1541A family transposase	-
M483_RS19065	3876389..3877966	-	1578	WP_002210983.1	transcriptional regulator TyrR	-
M483_RS19070	3878302..3878748	+	447	WP_002210982.1	DUF2384 domain-containing protein	Antitoxin
M483_RS19075	3878844..3879302	+	459	WP_002210981.1	RES family NAD+ phosphorylase	Toxin
M483_RS19080	3879312..3880373	-	1062	WP_002210980.1	YcjF family protein	-
M483_RS19085	3880370..3881767	-	1398	WP_011906190.1	YcjX family protein	-
M483_RS19090	3881748..3881990	-	243	WP_002216375.1	phage shock protein PspD	-
M483_RS19095	3882075..3882434	-	360	WP_002210977.1	envelope stress response membrane protein PspC	-
M483_RS19100	3882434..3882661	-	228	WP_002210976.1	envelope stress response membrane protein PspB	-
M483_RS19105	3882823..3883488	-	666	WP_002210975.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 16994.38 Da
• Isoelectric Point: 4.8732

>T45530 WP_002210981.1 NZ_CP006751:3878844-3879302 [Yersinia pestis 3770]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T45530 NZ_CP006751:3878844-3879302 [Yersinia pestis 3770]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16401.94 Da
• Isoelectric Point: 9.7155

>AT45530 WP_002210982.1 NZ_CP006751:3878302-3878748 [Yersinia pestis 3770]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT45530 NZ_CP006751:3878302-3878748 [Yersinia pestis 3770]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: A0A0E8XJV6

Antitoxin

• AlphaFold DB: A0A0E8XFL1