Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 3311096..3311742 Replicon chromosome
Accession NZ_CP006751
Organism Yersinia pestis 3770

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag M483_RS16405 Protein ID WP_002214976.1
Coordinates 3311560..3311742 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag M483_RS16400 Protein ID WP_002211129.1
Coordinates 3311096..3311515 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M483_RS16380 3306167..3307162 + 996 WP_002211125.1 substrate-binding domain-containing protein -
M483_RS16385 3307228..3308805 + 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
M483_RS16390 3308808..3309830 + 1023 WP_002214974.1 ABC transporter permease -
M483_RS16395 3309879..3310838 + 960 WP_002211128.1 sugar kinase -
M483_RS16400 3311096..3311515 - 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M483_RS16405 3311560..3311742 - 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
M483_RS16410 3311949..3312731 - 783 WP_002211130.1 flagellar type III secretion system protein FliR -
M483_RS16415 3312734..3313003 - 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
M483_RS16420 3313109..3313849 - 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
M483_RS16425 3313930..3314466 - 537 WP_002211133.1 flagellar biosynthetic protein FliO -
M483_RS16430 3314466..3314882 - 417 WP_011906247.1 flagellar motor switch protein FliN -
M483_RS16435 3314879..3315880 - 1002 WP_002211135.1 flagellar motor switch protein FliM -
M483_RS16440 3315886..3316356 - 471 WP_002227961.1 flagellar basal body-associated protein FliL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T45529 WP_002214976.1 NZ_CP006751:c3311742-3311560 [Yersinia pestis 3770]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T45529 NZ_CP006751:c3311742-3311560 [Yersinia pestis 3770]
GTGAAAAGTTCGGAGCTGATAAAACTGCTCGAAACAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCCAAAAAGGATGTTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT45529 WP_002211129.1 NZ_CP006751:c3311515-3311096 [Yersinia pestis 3770]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT45529 NZ_CP006751:c3311515-3311096 [Yersinia pestis 3770]
ATGGCTATCTATCCCGCCTATGTTCACGTTGATAATGATGGCTCGGCAAGCGGTTATTTCCCCGATGTCAAAGGCTGTAT
TTTTGCCATCAATGCCGGGGAGGATTTATTTGCAGAAGCATCAAGCGCCCTGGATGCACACTTTGAAGCTTTGGTGTCTG
AAGGTATCGAAATTCCTGAAGCTCATGACATGCCTTACCACGTTTACCGTAACCCATGCGATTACGCTGATGGCGGACAG
TGGTATAACGTGAATATTGATATGTCGAAATATGATGGAAAAGTTGAACGAATTAACGTCACTCTTCCGCACCGGCTGAT
TCATCAAATCGATACTATTGTTAAAGTGCGTCCCGAGTATGCCAGCCGAAGCAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References