Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 665314..665934 Replicon chromosome
Accession NZ_CP006751
Organism Yersinia pestis 3770

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag M483_RS04285 Protein ID WP_002208622.1
Coordinates 665731..665934 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag M483_RS04280 Protein ID WP_002218472.1
Coordinates 665314..665682 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M483_RS04265 663509..663769 + 261 WP_002208617.1 type B 50S ribosomal protein L31 -
M483_RS04270 663785..663928 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
M483_RS04275 664802..665155 + 354 WP_002208619.1 hypothetical protein -
M483_RS04280 665314..665682 + 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
M483_RS04285 665731..665934 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
M483_RS04290 666822..667211 + 390 WP_002208623.1 MGMT family protein -
M483_RS04295 667347..667868 - 522 WP_011906379.1 YbaY family lipoprotein -
M483_RS04300 668125..668985 + 861 WP_002208625.1 acyl-CoA thioesterase II -
M483_RS04305 669245..670534 - 1290 WP_002228344.1 ammonium transporter AmtB -
M483_RS04310 670574..670912 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T45518 WP_002208622.1 NZ_CP006751:665731-665934 [Yersinia pestis 3770]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T45518 NZ_CP006751:665731-665934 [Yersinia pestis 3770]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT45518 WP_002218472.1 NZ_CP006751:665314-665682 [Yersinia pestis 3770]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT45518 NZ_CP006751:665314-665682 [Yersinia pestis 3770]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCAGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References