Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1883296..1883968 Replicon chromosome
Accession NZ_CP006748
Organism Yersinia pestis 8787

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag M484_RS09915 Protein ID WP_002215144.1
Coordinates 1883296..1883721 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag M484_RS09920 Protein ID WP_002209939.1
Coordinates 1883702..1883968 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M484_RS09895 1878969..1879487 + 519 WP_002209934.1 flavodoxin FldB -
M484_RS09900 1879577..1881034 - 1458 WP_002220113.1 cell envelope integrity protein CreD -
M484_RS09905 1881155..1882573 - 1419 WP_002209936.1 two-component system sensor histidine kinase CreC -
M484_RS09910 1882598..1883296 - 699 WP_002209937.1 two-component system response regulator CreB -
M484_RS09915 1883296..1883721 - 426 WP_002215144.1 protein YgfX Toxin
M484_RS09920 1883702..1883968 - 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
M484_RS09925 1884285..1885277 + 993 WP_002209940.1 tRNA-modifying protein YgfZ -
M484_RS09930 1885350..1885847 - 498 WP_002209941.1 DUF2165 family protein -
M484_RS09935 1886105..1886806 - 702 WP_002209942.1 hemolysin III family protein -
M484_RS09940 1887008..1888111 - 1104 WP_002209943.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T45515 WP_002215144.1 NZ_CP006748:c1883721-1883296 [Yersinia pestis 8787]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T45515 NZ_CP006748:c1883721-1883296 [Yersinia pestis 8787]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCACACGGCATATTGGTCAT
TTTAACCTTGGTCGCGCCCTGGCCCTTGGGTTATACCGCCCTATGGCTGGTATTGCTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCGATGGAAAAGGCAT
GAATGGACCGTGGTCAAGCCGCCGTGGATCACCCGCTATGGGGTATTATTACATTTACAACAAACAGGCGGCCACGCGAC
CCGAAAGCGTCTATGGCTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTGCTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT45515 WP_002209939.1 NZ_CP006748:c1883968-1883702 [Yersinia pestis 8787]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT45515 NZ_CP006748:c1883968-1883702 [Yersinia pestis 8787]
ATGGAAATTGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGCTTGCTTGAGTGTGATGACCCAGATT
TATTCAACTGGCTGATGAACCACGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTCAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References