Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 807436..808436 Replicon chromosome
Accession NZ_CP006748
Organism Yersinia pestis 8787

Toxin (Protein)


Gene name - Uniprot ID A0A0E8XJV6
Locus tag M484_RS04810 Protein ID WP_002210981.1
Coordinates 807436..807894 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag M484_RS04815 Protein ID WP_002210982.1
Coordinates 807990..808436 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M484_RS04780 803250..803915 + 666 WP_002210975.1 phage shock protein PspA -
M484_RS04785 804077..804304 + 228 WP_002210976.1 envelope stress response membrane protein PspB -
M484_RS04790 804304..804663 + 360 WP_002210977.1 envelope stress response membrane protein PspC -
M484_RS04795 804748..804990 + 243 WP_002216375.1 phage shock protein PspD -
M484_RS04800 804971..806368 + 1398 WP_011906190.1 YcjX family protein -
M484_RS04805 806365..807426 + 1062 WP_002210980.1 YcjF family protein -
M484_RS04810 807436..807894 - 459 WP_002210981.1 RES family NAD+ phosphorylase Toxin
M484_RS04815 807990..808436 - 447 WP_002210982.1 DUF2384 domain-containing protein Antitoxin
M484_RS04820 808772..810349 + 1578 WP_002210983.1 transcriptional regulator TyrR -
M484_RS04825 810496..810954 - 459 WP_002213759.1 IS200/IS605-like element IS1541A family transposase -
M484_RS04830 811103..811882 - 780 WP_001297096.1 IS21-like element IS100kyp family helper ATPase IstB -
M484_RS04835 811882..812904 - 1023 WP_011901829.1 IS21-like element IS100 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16994.38 Da        Isoelectric Point: 4.8732

>T45512 WP_002210981.1 NZ_CP006748:c807894-807436 [Yersinia pestis 8787]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

>T45512 NZ_CP006748:c807894-807436 [Yersinia pestis 8787]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT45512 WP_002210982.1 NZ_CP006748:c808436-807990 [Yersinia pestis 8787]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp

>AT45512 NZ_CP006748:c808436-807990 [Yersinia pestis 8787]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E8XJV6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFL1

References