Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PIN-RelB
Location 1475852..1476705 Replicon chromosome
Accession NZ_CP006741
Organism Bifidobacterium longum subsp. longum GT15

Toxin (Protein)


Gene name relE Uniprot ID A0A0A0UEJ8
Locus tag BLGT_RS06270 Protein ID WP_038426455.1
Coordinates 1475852..1476343 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0A0UBX5
Locus tag BLGT_RS06275 Protein ID WP_038426456.1
Coordinates 1476343..1476705 (-) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BLGT_RS06250 1470923..1472155 + 1233 WP_007056207.1 sensor histidine kinase -
BLGT_RS06255 1472190..1472915 + 726 WP_007056206.1 response regulator transcription factor -
BLGT_RS06260 1472955..1473596 + 642 WP_007052627.1 GNAT family N-acetyltransferase -
BLGT_RS06265 1473686..1475791 + 2106 WP_038426454.1 DUF262 domain-containing protein -
BLGT_RS06270 1475852..1476343 - 492 WP_038426455.1 PIN domain-containing protein Toxin
BLGT_RS06275 1476343..1476705 - 363 WP_038426456.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BLGT_RS06280 1476851..1479550 - 2700 WP_013410771.1 aconitate hydratase AcnA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1357953..1523767 165814


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-141)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-53)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18273.79 Da        Isoelectric Point: 4.4719

>T45508 WP_038426455.1 NZ_CP006741:c1476343-1475852 [Bifidobacterium longum subsp. longum GT15]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAEAVMELGAKNNVTLLCASLSLKDIAYLSSSAIRSEFKPNESEVENFTRGF
LSSRVPWRCIEQVKEMCDIVAVDESTCDRAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISHFPEYCKTPAEIVA
ALE

Download         Length: 492 bp

>T45508 NZ_CP006741:c1476343-1475852 [Bifidobacterium longum subsp. longum GT15]
ATGACCGACGTTTCCATGCAGCGTATTTTGCTTGATACCAATGTACTGTTGGACTATTTGCTCCATCGCGATGATCACGC
CAAGATGGCGGAAGCGGTTATGGAACTTGGCGCGAAGAACAACGTTACGTTGTTGTGCGCGTCATTGTCGCTGAAGGATA
TCGCATACCTATCATCATCGGCGATTCGTAGCGAATTCAAACCGAATGAATCGGAAGTGGAGAATTTCACTCGCGGCTTT
CTGTCGTCACGGGTGCCATGGCGTTGTATCGAGCAGGTGAAGGAGATGTGTGACATCGTCGCTGTCGATGAGTCGACATG
TGATAGGGCTTTTTCCCTGCAAAAACGGCATCGGGATTTTGAAGATGATCTGATCATCGTTGCCGCGCAACAATCCGGTG
CCAACTGTGTGGTCACATCGGATGCCGAATTAATCAGTCATTTTCCCGAATATTGCAAAACACCGGCTGAAATCGTGGCG
GCGCTGGAATAA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13974.97 Da        Isoelectric Point: 4.7611

>AT45508 WP_038426456.1 NZ_CP006741:c1476705-1476343 [Bifidobacterium longum subsp. longum GT15]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRELKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDAYYNMKRAD

Download         Length: 363 bp

>AT45508 NZ_CP006741:c1476705-1476343 [Bifidobacterium longum subsp. longum GT15]
ATGACCATGGTCCAAATGAACGTTCGCATTGATGCGAAACTGAAGAACGAGGTCGAAGAAGTCCTCAAGGGCAAAGGCGT
ATCGGTGAGTGACGTAATCCGGTCGCTGTGGTTGTACATCGCCGACCGCAAGGAAGTGCCGGCATTGGAAACGACCGCCG
AAGAGCAAGCCCGCGAGGAGGAAAAGCAGCGCGAGCTGAAACTGATTCGAGAAGGTGCCGGATACGTGCACAAGGAACTG
GTCAAGGCCGGACTGATCTCAGAAGACACCGACCTCATGGAAGGCCTTACCTACAAGCAGTTCCGCGACAAAATGTACGA
CGAGCAACTTGATGCGTATTACAACATGAAGAGGGCCGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A0UEJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A0A0UBX5

References